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Published online before print July 11, 2007
Eur Respir J 2007, doi:10.1183/09031936.00152005
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ORIGINAL ARTICLE

Upregulation of proinflammatory cytokines in the intercostal muscles of COPD patients

C. Casadevall 1, C. Coronell 1, A.L. Ramírez-Sarmiento 1, J. Martínez-Llorens 1, E. Barreiro 1, M. Orozco-Levi 1, J. Gea 1*, the ENIGMA in COPD group

1 Muscle & Respiratory System Research Unit (URMAR), Servei de Pneumologia, Hospital del Mar - IMIM, Dpt CEXS, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain

* To whom correspondence should be addressed. E-mail: jgea{at}imim.es.


  Abstract

Muscle dysfunction is a characteristic feature of COPD. Recent studies suggest that cytokines may operate as local regulators of both muscle function and muscle regeneration. The aim of this study was to characterise the expression of different cytokines in the external intercostal muscle of COPD.

Muscle biopsies were obtained both from 25 stable COPD patients and 8 healthy controls. Local TNF-alpha, IL-1 beta, IL-6 and IL-10 expressions (real-time PCR and ELISA), sarcolemmal damage (immunohistochemistry), and the transcript levels of CD18 were assessed.

Muscle TNF-alpha and IL-6 transcripts were significantly higher in COPD patients compared to controls, and IL-1 beta and sarcolemmal damage showed a strong tendency in the same direction. Similar results were observed at the protein level. The CD18 panleukocyte marker was similar in COPD and controls. Respiratory muscle function was impaired in COPD patients, and it correlated to both the severity of lung function impairment and the TNF-alpha muscle expression.

COPD is associated with the upregulation of proinflammatory cytokines in the intercostal muscles. This phenomenon might be involved in respiratory muscle dysfunction.

Keywords:  Chronic lung disease, interleukin 1, interleukin 6, muscle function, respiratory muscle, tumour necrosis factor-alpha




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