Cysteinyl Leukotriene Receptor 1 Gene variation and Risk of Asthma in Chinese Population

¹ Mary Ann and J. Milburn Smith Child Health Research Program, Children's Memorial Hospital and Children's Memorial Research Center, Chicago, IL; and Center for Population Genetics, Division of Epidemiology and Biostatistics, School of Public Health M/C 923, University of Illinois at Chicago, Chicago, IL
² Program of Population Genetics, Harvard School of Public Health, Boston, MA
³ Mary Ann and J. Milburn Smith Child Health Research Program, Children's Memorial Hospital and Children's Memorial Research Center, Chicago, IL
⁴ Institute of Biomedicine, Anhui Medical University, Hefei, Anhui, China
⁵ Center for Population Genetics, Division of Epidemiology and Biostatistics, School of Public Health M/C 923, University of Illinois at Chicago, Chicago, IL

^* To whom correspondence should be addressed. E-mail: xipingxu{at}uic.edu.

	Abstract

While it has been recognized that genetics plays an important role in the development of asthma, important causal loci remain to be identified. This study was to examine the association of known and novel candidate genes with asthma.

Two independent samples, including 170 asthmatic cases and 347 controls in the initial sample, as well as 202 asthmatic cases and 332 controls in the confirmation sample, were recruited from the same region in China. 129 functional single nucleotide polymorphisms (SNPs) from 105 genes were genotyped using Sequenom MassArray technology and 119 SNPs were used for subsequent analysis.

In the initial sample, three SNPs, rs320995 in the CYSLTR1 gene, rs1047266 in the TNFRSF10B gene and rs40401 in the IL3 gene, were associated with the risk of asthma at P_observed <0.01. Notably, under the recessive genetic model, subjects without T-allele in SNP rs320995 had 3.1 times higher risk of asthma (P_observed=0.00004), which remained significant after accounting for multiple testing (P_global=0.047). This association was replicated in the confirmation sample (P=0.032) and validated by meta-analysis. Further, gender-specific analysis was performed, while no gender difference was found.

Our study has provided coherent evidence that CYSLTR1 variation is associated with the risk of asthma.

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