Published online before print
July 25, 2007
Eur Respir J 2007, doi:10.1183/09031936.00000607
CT screening for lung cancer: individualizing the benefit of the screening
C.I. Henschke 1*,
D.F. Yankelevitz 1,
R. Yip 1,
D.M. Libby 1,
M.W. Pasmantier 1,
J.P. Smith 1,
O.S. Miettinen 2,
The International Early Lung Cancer Action Program Investigators: (including Coordinating Center and Pathology Panel Investigators) (Writing Committee: Claudia I. Henschke PhD, MD, David F. Yankelevitz, MD, Rowena Yip, MPH, Daniel M. Libby, MD, Mark W. Pasmantier MD, James P. Smith MD, all at Weill Medical College of Cornell University, New York, NY and Olli S. Miettinen, MD, PhD, McGill University, Montreal, Canada) Joan & Sanford I. Weill Medical College of Cornell University, New York, NY Claudia I. Henschke, Principal Investigator, David F. Yankelevitz, Dorothy I. McCauley Azumi General Hospital, Nagano, Japan Shusuke Sone, Takaomi Hanaoka CBNS, City University of New York at Queens College, Queens, NY Steven Markowitz, Albert Miller LungenZentrum Hirslanden, Zurich, Switzerland Karl Klingler, Thomas Scherer, Rolf Inderbitzi Clinica Universitaria de Navarra, Pamplona, Spain Javier Zulueta, Luis Montuenga, Gorka Bastarrika National Cancer Institute Regina Elena, Rome, Italy Salvatore Giunta, Marcello Crecco, Patrizia Pugliese H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL Melvyn Tockman Hadassah Medical Organization, Jerusalem, Israel Dorith Shaham Swedish Medical Center, Seattle, WA Kim Rice, Ralph Aye University of Toronto, Princess Margaret Hospital, Toronto, Canada Heidi Roberts, Demetris Patsios Christiana Care, Helen F. Graham Cancer Center, Newark, DE Thomas Bauer, James Lally Columbia University Medical Center, New York, NY John H.M. Austin, Gregory D. N. Pearson New York University Medical Center, New York, NY David Naidich, Georgeann McGuinness State University of New York at Stony Brook, Stony Brook, NY Matthew Rifkin, Edward Fiore Maimonides Medical Center, Brooklyn, NY Samuel Kopel Roswell Park Cancer Institute, Buffalo, NY Donald Klippenstein, Alan Litwin, Peter A. Loud State University of New York, Upstate Medical Center, Syracuse, NY Leslie J. Kohman, Ernest M. Scalzetti North ShoreLong Island Jewish Health System, New Hyde Park, NY Arfa Khan, Rakesh Shah Georgia Institute for Lung Cancer Research, Atlanta, GA Michael V. Smith, Hadyn T. Williams, Louis Lovett Mount Sinai School of Medicine, New York, NY David S. Mendelson Jackson Memorial Hospital, University of Miami, Miami, FL Richard Thurer Memorial SloanKettering Cancer Center, New York, NY Robert T. Heelan, Michelle S. Ginsberg Holy Cross Hospital Cancer Institute, Silver Spring, MD Frank Sullivan, Marlana Ottinger Eisenhower Lucy Curci Cancer Center, Rancho Mirage, CA Davood Vafai New York Medical College, Valhalla, NY Terence A.S. Matalon Mount Sinai Comprehensive Cancer Center, Miami Beach, FL ShariLynn Odzer The 5th Affiliated Hospital of Sun YatSen University, Zhuhai, China Xueguo Liu Dorothy E. Schneider Cancer Center, MillsPeninsula Health Services, San Mateo, CA Barry Sheppard St.Agnes Cancer Center, Baltimore, MD Enser Cole Our Lady of Mercy Medical Center, Bronx, NY Peter H. Wiernik Evanston Northwestern Healthcare Medical Group, Evanston, IL Daniel Ray Karmanos Cancer Institute, Detroit, MI Harvey Pass, Carmen Endress Greenwich Hospital, Greenwich, CT David Mullen Sharp Memorial Hospital, San Diego, CA Michael Kalafer City of Hope National Medical Center, Duarte, CA Fred Grannis, Arnold Rotter ProHealth Care Regional Cancer Center, Waukesha & Oconomowoc Memorial Hospitals, Oconomowoc, WI, M. Kristin Thorsen, Richard Hansen Comprehensive Cancer Center, Desert Regional Medical Center, Palm Springs, CA Elber Camacho St. Joseph Health Center, St. Charles, MO Dan Luedke
1 Weill Medical College of Cornell University, New York, NY
2 McGill University, Montreal, Canada
 |
Abstract |
|---|
Individuals concerned about their risk for lung cancer are recommended to talk with their physicians about CT screening for lung cancer. Needed is the survival benefit of the screening, specific to a particular person for a particular round of screening. The probability of survival gain for the first, baseline round of screening was addressed as the product of: 1) the screening resulting in the diagnosis of lung cancer; 2) not dying from some other cause in a sufficiently long period of time, and 3) cure resulting from pre-symptomatic treatment of lung cancer and these probabilities were estimated using the I-ELCAP data on individuals 40–85 years of age with a history of 0–150 pack-years of cigarette smoking. The estimated probability of survival gain ranged from 0.4% for a 60-year old with 10 pack-years of smoking who quit 20 years ago, to 3.1% for a 70-year-old current smoker with 100 pack-years and 2.0%, for a 85-year-old current smoker with 150 pack-years. When seeking counsel about initiation of screening for lung cancer, an estimate of the probability of survival gain from the first round of CT screening, specific to the person's age and history of smoking can be provided.
Keywords:
International Early Lung Cancer Action Program, lung cancer, survival
This article has been cited by other articles:
|
|
|
|
 
C. I. Henschke and D. F. Yankelevitz
CT Screening for Lung Cancer: Update 2007
Oncologist,
January 1, 2008;
13(1):
65 - 78.
[Abstract]
[Full Text]
[PDF]
|
|
|
Copyright © 2007 by the European Respiratory Society.
|
