ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cathomas, G
Right arrow Articles by Dalquen, P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cathomas, G
Right arrow Articles by Dalquen, P
Eur Respir J 1996; 9: 1743-1746
Copyright © ERS Journals Ltd 1996

Original Articles

Detection of herpesvirus-like DNA in the bronchoalveolar lavage fluid of patients with pulmonary Kaposi's sarcoma

G Cathomas, M Tamm, CE McGandy, AP Perruchoud, MJ Mihatsch, and P Dalquen

Pulmonary involvement is a clinically important form of visceral Kaposi's sarcoma in immunocompromised patients. Recently, herpesvirus-like deoxyribonucleic acid (DNA) sequences, defining a new herpesvirus termed "human herpesvirus 8" (HHV8) or "Kaposi's sarcoma-associated herpesvirus" (KSHV), were detected in Kaposi's sarcoma of acquired immune deficiency syndrome (AIDS) and non-AIDS patients. We describe the successful detection of HHV8 DNA in the bronchoalveolar lavage (BAL) fluid of patients with pulmonary Kaposi's sarcoma. Three immunocompromised patients, two HIV seropositive and one after kidney transplantation, suffered from respiratory symptoms and showed pulmonary infiltrates on chest radiography after development of biopsy proven Kaposi's sarcoma of the skin. Bronchoscopy revealed the typical Kaposi like livid endobronchial lesions. BAL fluid was analysed for the presence of HHV8 DNA using a nested polymerase chain reaction (PCR) assay. HHV8 DNA was detected in the BAL fluid of all three patients. In addition, HHV8 DNA could be detected in the skin biopsy tissue, lymph node, and peripheral blood mononuclear cells of these patients. Our data show that human herpesvirus 8 deoxyribonucleic acid can be detected in the bronchoalveolar lavage fluid of patients with pulmonary Kaposi's sarcoma. If further studies reveal a high specificity for human herpesvirus 8 deoxyribonucleic acid detection, this test will improve the tools for the diagnosis of pulmonary Kaposi's sarcoma without further need of biopsies.


This article has been cited by other articles:


Home page
 J. Virol.Home page
K. Kosulin, C. Haberler, J. A. Hainfellner, G. Amann, S. Lang, and T. Lion
Investigation of Adenovirus Occurrence in Pediatric Tumor Entities
J. Virol., July 15, 2007; 81(14): 7629 - 7635.
[Abstract] [Full Text] [PDF]

Home page
 ImagingHome page
L J King and S P G Padley
Imaging of the thorax in AIDS
Imaging, February 1, 2002; 14(1): 60 - 76.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
S. Barete, V. Calvez, C. Mouquet, B. Barrou, H. Kreis, J. Dantal, R. Dorent, F. Durand, Y. Dimitrov, N. Dupin, et al.
Clinical Features and Contribution of Virological Findings to the Management of Kaposi Sarcoma in Organ-Allograft Recipients
Arch Dermatol, December 1, 2000; 136(12): 1452 - 1458.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. TAMM, F. REICHENBERGER, C. E. MCGANDY, A. STALDER, A. TIETZ, P. DALQUEN, A. P. PERRUCHOUD, and G. CATHOMAS
Diagnosis of Pulmonary Kaposi's Sarcoma by Detection of Human Herpes Virus 8 in Bronchoalveolar Lavage
Am. J. Respir. Crit. Care Med., February 1, 1997; 157(2): 458 - 463.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the European Respiratory Society.