ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yanagawa, H
Right arrow Articles by Sone, S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yanagawa, H
Right arrow Articles by Sone, S
Eur Respir J 1996; 9: 1211-1216
Copyright © ERS Journals Ltd 1996

Original Articles

Interleukin-1 receptor antagonist in pleural effusion due to inflammatory and malignant lung disease

H Yanagawa, S Yano, T Haku, Y Ohmoto, and S Sone

Interleukin (IL)-1 is a key cytokine in inflammatory reactions. To clarify the mechanism of inflammation in the pleural cavity, we investigated the contribution of IL-1 and its antagonism to inflammatory processes in the pleural cavity. Interleukin-1 receptor antagonist (IL-1Ra) levels as well as IL-1 beta and interferon-gamma (IFN-gamma) levels were measured by enzyme immunoassay in pleural effusions from 70 patients. Pleural macrophages were also examined as possible sources of these cytokines in 10 patients. IL-1Ra was detectable in 28 patients (40%) out of 70 patients with pleural effusions. Patients with tuberculosis had significantly higher IL-1Ra as well as IFN-gamma levels in pleural effusion than patients with lung cancer. Transudative pleural effusions had low or undetectable IL-IRa levels. On the other hand, IL-1 beta levels were low, except in cases of parapneumonic pleural effusion. Spontaneous production of IL-1Ra pleural macrophages was observed in six patients, and IL-4 significantly augmented its production. Although spontaneous production of IL-1 beta was observed in only two patients, pleural macrophages produced significant amounts of IL-1 beta in response to lipopolysaccharide in all 10 patients examined. These results suggest that interleukin-1 receptor antagonist regulates various reactions by interleukin-1 in pleural effusion, and that pleural macrophages may act in situ as a source of interleukin-1 receptor antagonist.


This article has been cited by other articles:


Home page
 ChestHome page
J. Jiang, H.-Z. Shi, Q.-L. Liang, S.-M. Qin, and X.-J. Qin
Diagnostic Value of Interferon-{gamma} in Tuberculous Pleurisy: A Metaanalysis
Chest, April 1, 2007; 131(4): 1133 - 1141.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C.-C. Hua, L.-C. Chang, Y.-C. Chen, and S.-C. Chang
Proinflammatory Cytokines and Fibrinolytic Enzymes in Tuberculous and Malignant Pleural Effusions
Chest, November 1, 1999; 116(5): 1292 - 1296.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
D. M. Atwell, K. P. Grichnik, M. F. Newman, J. G. Reves, and W. T. McBride
Balance of proinflammatory and antiinflammatory cytokines at thoracic cancer operation
Ann. Thorac. Surg., October 1, 1998; 66(4): 1145 - 1150.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. MARIE, M.-R. LOSSER, C. FITTING, N. KERMARREC, D. PAYEN, and J.-M. CAVAILLON
Cytokines and Soluble Cytokine Receptors in Pleural Effusions from Septic and Nonseptic Patients
Am. J. Respir. Crit. Care Med., November 1, 1997; 156(5): 1515 - 1522.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the European Respiratory Society.