| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Articles |
The association of chronic mucus hypersecretion and mortality is a matter of debate. We wished to determine whether the relationship between chronic mucus hypersecretion and chronic obstructive pulmonary disease (COPD)-related mortality could be explained by proneness to pulmonary infection. We followed 14,223 subjects of both sexes for 10-12 yrs. Cases where COPD was an underlying or contributory cause of death (n = 214) were included, and hospital records were obtained when possible (n = 101). From the presence of increased mucus, purulent mucus, fever, leucocytosis and infiltration on chest radiography, death was classified as either due to pulmonary infection (n = 38), other causes (n = 51), or unclassifiable (n = 12). Of subjects reporting chronic mucus hypersecretion at the initial examination, pulmonary infection was implicated in 54% of deaths, whereas this only occurred in 28% of subjects without chronic mucus hypersecretion. Controlling for covariates, in particular smoking habits, a Cox analysis showed a strong inverse relationship between ventilatory function and COPD-related mortality. Chronic mucus hypersecretion was found to be a significant predictor of COPD-related death with pulmonary infection implicated (relative risk (RR) 3.5) but not of death without pulmonary infection (RR 0.9). We consider that subjects with COPD and chronic mucus hypersecretion are more likely to die from pulmonary infections than subjects without chronic mucus hypersecretion. This may explain the excess mortality in subjects with COPD and chronic mucus hypersecretion found in previous studies.
This article has been cited by other articles:
|
|
 |
|
  K. F. Chung and I. M. Adcock Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction Eur. Respir. J., June 1, 2008; 31(6): 1334 - 1356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E Sapey, D Bayley, A Ahmad, P Newbold, N Snell, and R A Stockley Inter-relationships between inflammatory markers in patients with stable COPD with bronchitis: intra-patient and inter-patient variability Thorax, June 1, 2008; 63(6): 493 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Kim, T. J. Rogers, and G. J. Criner New Concepts in the Pathobiology of Chronic Obstructive Pulmonary Disease Proceedings of the ATS, May 1, 2008; 5(4): 478 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. MacNee Update in Chronic Obstructive Pulmonary Disease 2007 Am. J. Respir. Crit. Care Med., April 15, 2008; 177(8): 820 - 829. [Full Text] [PDF]
|
|
|
|
|
|
J. B. Snoeck-Stroband, T. S. Lapperre, M. M. E. Gosman, H. M. Boezen, W. Timens, N. H. T. ten Hacken, J. K. Sont, P. J. Sterk, P. S. Hiemstra, and the Groningen Leiden Universities Corticosteroids Chronic bronchitis sub-phenotype within COPD: inflammation in sputum and biopsies Eur. Respir. J., January 1, 2008; 31(1): 70 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. W. Williams, A. Sharafkhaneh, V. Kim, B. F. Dickey, and C. M. Evans Airway Mucus: From Production to Secretion Am. J. Respir. Cell Mol. Biol., May 1, 2006; 34(5): 527 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G C Donaldson and J A Wedzicha COPD exacerbations {middle dot} 1: Epidemiology Thorax, February 1, 2006; 61(2): 164 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Wilson Treatment of COPD exacerbations: antibiotics Eur. Respir. Rev., September 1, 2005; 14(94): 32 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Vestbo Chronic bronchitis: should it worry us? Chronic Respiratory Disease, July 1, 2004; 1(3): 173 - 176. [Abstract] [PDF]
|
|
|
|
|
|
The pharmacoepidemiology of COPD: Recent advances and methodological discussion Eur. Respir. J., September 1, 2003; 22(43_suppl): 1s - 44s. [Full Text] [PDF]
|
|
|
|
|
|
S. Burge and J.A. Wedzicha COPD exacerbations: definitions and classifications Eur. Respir. J., June 1, 2003; 21(41_suppl): 46S - 53s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.M.J.M. Gerrits, R.M.C. Herings, H.G.M. Leufkens, and J-W.J. Lammers N-acetylcysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease Eur. Respir. J., May 1, 2003; 21(5): 795 - 798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I S Patel, T A R Seemungal, M Wilks, S J Lloyd-Owen, G C Donaldson, and J A Wedzicha Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations Thorax, September 1, 2002; 57(9): 759 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Miravitlles Exacerbations of chronic obstructive pulmonary disease: when are bacteria important? Eur. Respir. J., July 1, 2002; 20(36_suppl): 9S - 19s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. MacNee Airway Infection Does Not Accelerate Decline in Lung Function in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): 1758 - 1759. [Full Text] [PDF]
|
|
|
|
|
|
J.M. Anto, P. Vermeire, J. Vestbo, and J. Sunyer Epidemiology of chronic obstructive pulmonary disease Eur. Respir. J., May 1, 2001; 17(5): 982 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wilson Bacteria, antibiotics and COPD Eur. Respir. J., May 1, 2001; 17(5): 995 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. Jeffery Comparison of the Structural and Inflammatory Features of COPD and Asthma Giles F. Filley Lecture Chest, May 1, 2000; 117(5_suppl_1): 251S - 260S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. A. Calverley COPD : Early Detection and Intervention Chest, May 1, 2000; 117(5_suppl_2): 365S - 371S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. F. Voelkel and R. Tuder COPD : Exacerbation Chest, May 1, 2000; 117(5_suppl_2): 376S - 379S. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
