|
|
||||||||
Original Articles |
It is now well-established that sensory nerves stimulation in the airway induces bronchoconstriction and inflammation, but also protective reflexes, such as coughing. These effects are mediated through the release of tachykinins (substance P and neurokinin A) and we have recently shown that SR 48968, a tachykinin NK2-receptor antagonist, inhibited cough induced by citric acid. In this paper, we have studied the effects of SR 48968 administered by aerosol. We have also investigated the effects of SR 140333, a tachykinin NK1-receptor antagonist, and the combination of both SR 48968 and SR140333 to determine whether tachykinin NK1 receptors are involved in cough. Finally, we have studied the combined effects of SR 48968 and salbutamol to find out whether the antitussive effect of SR 48968 is a consequence of the inhibition of bronchoconstriction. Unanaesthetized guinea-pigs were placed in a transparent chamber and exposed to an aerosol of citric acid (0.4 M). The number of coughs was counted by visual inspection and by determination of sounds and pressure variations in the chamber. By the aerosol route, SR 48968 was an efficient antitussive and 16 times more potent than codeine. SR 140333 (0.1-1 mg.kg-1 i.p.) did not exert any antitussive effect but it potentiated the maximal effect induced by SR 48968. Finally, salbutamol, in a dose (0.3 mg.kg-1) which inhibits bronchoconstriction, but not cough induced by citric acid, did not modify the antitussive effect of SR 48968.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
![]() |
A H Morice, L McGarvey, I Pavord, and on behalf of the British Thoracic Society Cough Gu Recommendations for the management of cough in adults Thorax, September 1, 2006; 61(suppl_1): i1 - i24. [Full Text] [PDF] |
||||
![]() |
A.H. Morice and committee members The diagnosis and management of chronic cough Eur. Respir. J., September 1, 2004; 24(3): 481 - 492. [Full Text] [PDF] |
||||
![]() |
M G Belvisi and P Geppetti Cough * 7: Current and future drugs for the treatment of chronic cough Thorax, May 1, 2004; 59(5): 438 - 440. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Emonds-Alt, V. Proietto, R. Steinberg, F. Oury-Donat, X. Vige, P. Vilain, E. Naline, S. Daoui, C. Advenier, G. Le Fur, et al. SSR240600 [(R)-2-(1-{2-[4-{2-[3,5-Bis(trifluoromethyl)phenyl]acetyl}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl}- 4-piperidinyl)-2-methylpropanamide], a Centrally Active Nonpeptide Antagonist of the Tachykinin Neurokinin-1 Receptor: I. Biochemical and Pharmacological Characterization J. Pharmacol. Exp. Ther., December 1, 2002; 303(3): 1171 - 1179. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Katsunuma, A. F. Roffel, C. R. S. Elzinga, J. Zaagsma, P. J. Barnes, and J. C. W. Mak beta 2-Adrenoceptor Agonist-Induced Upregulation of Tachykinin NK2 Receptor Expression and Function in Airway Smooth Muscle Am. J. Respir. Cell Mol. Biol., September 1, 1999; 21(3): 409 - 417. [Abstract] [Full Text] |
||||
![]() |
A. Xiang, Y. Uchida, A. Nomura, H. Iijima, F. Dong, M.-J. Zhang, and S. Hasegawa Effects of airway inflammation on cough response in the guinea pig J Appl Physiol, November 1, 1998; 85(5): 1847 - 1854. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. DAOUI, C. COGNON, E. NALINE, X. EMONDS-ALT, and C. ADVENIER Involvement of Tachykinin NK3 Receptors in Citric Acid-induced Cough and Bronchial Responses in Guinea Pigs Am. J. Respir. Crit. Care Med., July 1, 1998; 158(1): 42 - 48. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |