ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shirai, M
Right arrow Articles by Chida, K
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shirai, M
Right arrow Articles by Chida, K
Eur Respir J 1995; 8: 272-277
Copyright © ERS Journals Ltd 1995

Original Articles

The influence of ovarian hormones on the granulomatous inflammatory process in the rat lung

M Shirai, A Sato, and K Chida

This study was initiated to clarify the relationship between ovarian hormones and the granulomatous inflammatory process in the lung. To assess whether ovarian dysfunction influences the granulomatous inflammatory process, we compared immunological alterations in ovariectomized rats and in sham-operated rats. After a heat-killed, bacilli Calmette-Guerin (BCG)-elicited granulomatous reaction, the lung-body weight ratios, the number of lymphocytes and activated T-cells, and the interferon-gamma levels in the bronchoalveolar lavage fluid from the ovariectomized rats were significantly higher than those of the sham-operated rats. Moreover, exogenous ovarian steroids supplemented in vivo suppressed not only the granulomatous inflammatory process in the lungs, but also the parameters measured in the bronchoalveolar fluid. These results indicate that ovarian dysfunction may adversely affect the formation of granulomas in the lung.


This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
J. W. Card and D. C. Zeldin
Hormonal Influences on Lung Function and Response to Environmental Agents: Lessons from Animal Models of Respiratory Disease
Proceedings of the ATS, December 1, 2009; 6(7): 588 - 595.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. C. Catley, M. A. Birrell, E. L. Hardaker, J. de Alba, S. Farrow, S. Haj-Yahia, and M. G. Belvisi
Estrogen Receptor {beta}: Expression Profile and Possible Anti-Inflammatory Role in Disease
J. Pharmacol. Exp. Ther., July 1, 2008; 326(1): 83 - 88.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. W. Card, M. A. Carey, J. A. Bradbury, L. M. DeGraff, D. L. Morgan, M. P. Moorman, G. P. Flake, and D. C. Zeldin
Gender Differences in Murine Airway Responsiveness and Lipopolysaccharide-Induced Inflammation
J. Immunol., July 1, 2006; 177(1): 621 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Gharaee-Kermani, K. Hatano, Y. Nozaki, and S. H. Phan
Gender-Based Differences in Bleomycin-Induced Pulmonary Fibrosis
Am. J. Pathol., June 1, 2005; 166(6): 1593 - 1606.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Tsuchiya, K. Chida, T. Suda, E. E. Schneeberger, and H. Nakamura
Dendritic Cell Involvement in Pulmonary Granuloma Formation Elicited by Bacillus Calmette-Guerin in Rats
Am. J. Respir. Crit. Care Med., June 15, 2002; 165(12): 1640 - 1646.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Cuzzocrea, S. Santagati, L. Sautebin, E. Mazzon, G. Calabro, I. Serraino, A. P. Caputi, and A. Maggi
17{beta}-Estradiol Antiinflammatory Activity in Carrageenan-Induced Pleurisy
Endocrinology, April 1, 2000; 141(4): 1455 - 1463.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the European Respiratory Society.