ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seersholm, N
Right arrow Articles by Kok-Jensen, A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seersholm, N
Right arrow Articles by Kok-Jensen, A
Eur Respir J 1994; 7: 1985-1987
Copyright © ERS Journals Ltd 1994

Original Articles

Airways obstruction and two year survival in patients with severe alpha 1-antitrypsin deficiency

N Seersholm, A Dirksen, and A Kok-Jensen

Because of the limited number of donor organs available, the selection of patients for lung transplantation is crucial. One important issue in setting priorities is the life expectancy without transplantation. The purpose of this study was to estimate survival based on lung function, in alpha 1-antitrypsin deficient patients. Data from the Danish alpha 1-antitrypsin deficiency registry were analysed. The basic element of the analysis was two year intervals, characterized by date of spirometry and known mortality status 2 yrs later. We found a simple exponential relationship between lung function (forced expiratory volume one second (FEV1)) and two year survival on conservative treatment. The formula implies an almost 100% two year survival until FEV1 falls below one third of predicted normal; at this level two year mortality increases and will reach 50% at a FEV1 of 15% predicted. In conclusion, the two year mortality of emphysema patients due to alpha 1-antitrypsin deficiency increases exponentially with decreasing FEV1 and the results imply that only a few patients who underwent lung transplantation would have had a better two year prognosis without this procedure.


This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
O. A. Minai, J. Benditt, and F. J. Martinez
Natural History of Emphysema
Proceedings of the ATS, May 1, 2008; 5(4): 468 - 474.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. A. Lomas
The Selective Advantage of {alpha}1-Antitrypsin Deficiency
Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1072 - 1077.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
V. Cottin, H. Nunes, P-Y. Brillet, P. Delaval, G. Devouassoux, I. Tillie-Leblond, D. Israel-Biet, I. Court-Fortune, D. Valeyre, J-F. Cordier, et al.
Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity
Eur. Respir. J., October 1, 2005; 26(4): 586 - 593.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. K. Stoller, J. Tomashefski Jr, R. G. Crystal, A. Arroliga, C. Strange, D. N. Killian, M. D. Schluchter, H. P. Wiedemann, and for the α1-Antitrypsin Deficiency Registry S
Mortality in Individuals With Severe Deficiency of α1-Antitrypsin: Findings From the National Heart, Lung, and Blood Institute Registry
Chest, April 1, 2005; 127(4): 1196 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
American Thoracic Society/European Respiratory Society Statement: Standards for the Diagnosis and Management of Individuals with Alpha-1 Antitrypsin Deficiency
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 818 - 900.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
The Alpha-1-Antitrypsin Deficiency Registry Study 
Survival and FEV1 Decline in Individuals with Severe Deficiency of alpha 1-Antitrypsin
Am. J. Respir. Crit. Care Med., July 1, 1998; 158(1): 49 - 59.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
International Guidelines for the Selection of Lung Transplant Candidates
Am. J. Respir. Crit. Care Med., July 1, 1998; 158(1): 335 - 339.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by the European Respiratory Society.