| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Trial |
Partial bronchodilator reversibility can be demonstrated in many patients with stable chronic obstructive pulmonary disease (COPD), but its relevance to exercise capacity and symptoms is uncertain. Previous data suggest that anticholinergic bronchodilators do not improve exercise tolerance in such patients. We studied 32 patients with stable COPD, mean age 65 yrs, in a double-blind, placebo-controlled, cross-over trial of the inhaled anticholinergic drug, oxitropium bromide. From the within and between day placebo spirometry, we derived the spontaneous variation in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) of this population (FEV1 140 ml; FVC 390 ml) and considered responses beyond this to be significant. Oxitropium bromide increased baseline FEV1 from 0.70 (0.28) l (mean (SD)) to 0.88 (0.36) l. The 6 min walking distance increased by 7% compared with placebo, whilst resting breathlessness scores fell from 2.0 to 1.23 at rest and 4.09 to 3.28 at the end of exercise after the active drug. Improvements in walking distances and symptoms were unrelated to changes in either FEV1 or FVC, indicating that routine reversibility testing is not a good predictor of symptomatic benefit in these patients.
This article has been cited by other articles:
|
|
 |
|
  B. R. Celli Update on the Management of COPD Chest, June 1, 2008; 133(6): 1451 - 1462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Albert and P. M. A. Calverley Drugs (including oxygen) in severe COPD Eur. Respir. J., May 1, 2008; 31(5): 1114 - 1124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al. Outcomes for COPD pharmacological trials: from lung function to biomarkers Eur. Respir. J., February 1, 2008; 31(2): 416 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Pepin, J. Brodeur, Y. Lacasse, J. Milot, P. LeBlanc, F. Whittom, and F. Maltais Six-minute walking versus shuttle walking: responsiveness to bronchodilation in chronic obstructive pulmonary disease Thorax, April 1, 2007; 62(4): 291 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. A. Calverley Dynamic Hyperinflation: Is It Worth Measuring? Proceedings of the ATS, May 1, 2006; 3(3): 239 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Celli Chronic Obstructive Pulmonary Disease: From Unjustified Nihilism to Evidence-based Optimism. Proceedings of the ATS, January 1, 2006; 3(1): 58 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Stevenson, P. P. Walker, R. W. Costello, and P. M. A. Calverley Lung Mechanics and Dyspnea during Exacerbations of Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., December 15, 2005; 172(12): 1510 - 1516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Aliverti, K Rodger, R L Dellaca, N Stevenson, A Lo Mauro, A Pedotti, and P M A Calverley Effect of salbutamol on lung function and chest wall volumes at rest and during exercise in COPD Thorax, November 1, 2005; 60(11): 916 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Cote and B. R. Celli Pulmonary rehabilitation and the BODE index in COPD Eur. Respir. J., October 1, 2005; 26(4): 630 - 636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. A. Calverley Long-acting inhaled bronchodilators in COPD: how many drugs do we need? Eur. Respir. J., August 1, 2005; 26(2): 190 - 191. [Full Text] [PDF]
|
|
|
|
|
|
N J Stevenson and P M A Calverley Effect of oxygen on recovery from maximal exercise in patients with chronic obstructive pulmonary disease Thorax, August 1, 2004; 59(8): 668 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P M A Calverley Breathlessness during exercise in COPD: how do the drugs work? Thorax, June 1, 2004; 59(6): 455 - 457. [Full Text] [PDF]
|
|
|
|
|
|
P M A Calverley, P S Burge, S Spencer, J A Anderson, and P W Jones Bronchodilator reversibility testing in chronic obstructive pulmonary disease Thorax, August 1, 2003; 58(8): 659 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.I. Rennard and P. Calverley Rescue! Therapy and the paradox of the Barcalounger Eur. Respir. J., June 1, 2003; 21(6): 916 - 917. [Full Text] [PDF]
|
|
|
|
|
|
T. Oga, K. Nishimura, M. Tsukino, S. Sato, T. Hajiro, and M. Mishima A Comparison of the Effects of Salbutamol and Ipratropium Bromide on Exercise Endurance in Patients With COPD Chest, June 1, 2003; 123(6): 1810 - 1816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W MacNee and P M A Calverley Chronic obstructive pulmonary disease * 7: Management of COPD Thorax, March 1, 2003; 58(3): 261 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Di Marco, J. Milic-Emili, B. Boveri, P. Carlucci, P. Santus, F. Casanova, M. Cazzola, and S. Centanni Effect of inhaled bronchodilators on inspiratory capacity and dyspnoea at rest in COPD Eur. Respir. J., January 1, 2003; 21(1): 86 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wadbo, C-G. Lofdahl, K. Larsson, B.E. Skoogh, G. Tornling, E. Arwestrom, T. Bengtsson, and K. Strom Effects of formoterol and ipratropium bromide in COPD: a 3-month placebo-controlled study Eur. Respir. J., November 1, 2002; 20(5): 1138 - 1146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
ATS Statement: Guidelines for the Six-Minute Walk Test Am. J. Respir. Crit. Care Med., July 1, 2002; 166(1): 111 - 117. [Full Text] [PDF]
|
|
|
|
|
|
C A E Dyer, S J Singh, R A Stockley, A J Sinclair, and S L Hill The incremental shuttle walking test in elderly people with chronic airflow limitation Thorax, January 1, 2002; 57(1): 34 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Hadcroft and P M A Calverley Alternative methods for assessing bronchodilator reversibility in chronic obstructive pulmonary disease Thorax, September 1, 2001; 56(9): 713 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.M.A. Calverley Modern treatment of chronic obstructive pulmonary disease Eur. Respir. J., July 2, 2001; 18(34_suppl): 60S - 66s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. TAUBE, B. LEHNIGK, K. PAASCH, D. K. KIRSTEN, R. A. JÖRRES, and H. MAGNUSSEN Factor Analysis of Changes in Dyspnea and Lung Function Parameters after Bronchodilation in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., July 1, 2000; 162(1): 216 - 220. [Abstract] [Full Text]
|
|
|
|
|
|
T. OGA, K. NISHIMURA, M. TSUKINO, T. HAJIRO, A. IKEDA, and T. IZUMI The Effects of Oxitropium Bromide on Exercise Performance in Patients with Stable Chronic Obstructive Pulmonary Disease . A Comparison of Three Different Exercise Tests Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 1897 - 1901. [Abstract] [Full Text]
|
|
|
|
|
|
J A van Noord, T A Bantje, M E Eland, L Korducki, and P J G Cornelissen A randomised controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease Thorax, April 1, 2000; 55(4): 289 - 294. [Abstract] [Full Text]
|
|
|
|
|
|
D. E. O'Donnell Assessment of Bronchodilator Efficacy in Symptomatic COPD : Is Spirometry Useful? Chest, February 1, 2000; 117(2_suppl): 42S - 47S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. O'DONNELL, M. LAM, and K. A. WEBB Spirometric Correlates of Improvement in Exercise Performance after Anticholinergic Therapy in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., August 1, 1999; 160(2): 542 - 549. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Davies, M. Nisar, M.G. Pearson, R.W. Costello, J.E. Earis, and P.M.A. Calverley Oral corticosteroid trials in the management of stable chronic obstructive pulmonary disease QJM, July 1, 1999; 92(7): 395 - 400. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
