31P-nuclear magnetic resonance evidence of abnormal skeletal muscle metabolism in patients with chronic lung disease and congestive heart failure

The development of 31P-nuclear magnetic resonance (NMR) has enabled direct and non-invasive measurements of muscle metabolism. Serial measurements of the phosphocreatine/inorganic phosphate (PCr/Pi) ratio, which is closely related to the adenosine triphosphate/adenosine diphosphate (ATP/ADP) ratio and pH during and after forearm exercise were performed in 11 patients with chronic lung disease (CLD), nine patients with chronic heart failure (CHF) and eight control subjects. As compared with control subjects, the PCr/Pi ratio in the patients with CLD or CHF was lower during the recovery period and significantly lower at three and 4 min exercise. The pH values after exercise were lower in patients with CLD or CHF compared to control subjects. The PCr/Pi ratio at 4 min after exercise in the patients with CLD or CHF did not correlate with parameters of cardiac function or arterial and mixed venous oxygen tension. The arterial oxygen content and output in patients with CLD and CHF were significantly lower than that of control subjects. Nutritional parameters were not statistically different among the three groups. These observations suggest that metabolic abnormalities may be present in the skeletal muscles of patients with CLD and CHF that are not due to under-nutrition. These may result from reduced arterial oxygen output and, partially, from physical detraining.

This article has been cited by other articles:

				E. Barreiro, J. Gea, G. Matar, and S. N.A. Hussain Expression and Carbonylation of Creatine Kinase in the Quadriceps Femoris Muscles of Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Cell Mol. Biol., December 1, 2005; 33(6): 636 - 642. [Abstract] [Full Text] [PDF]

				J. P Mattson and J. C Martin Emphysema-induced reductions in locomotory skeletal muscle contractile function Exp Physiol, July 1, 2005; 90(4): 519 - 525. [Abstract] [Full Text] [PDF]

				P. McDonough, B. J. Behnke, T. I. Musch, and D. C. Poole Recovery of microvascular PO2 during the exercise off-transient in muscles of different fiber type J Appl Physiol, March 1, 2004; 96(3): 1039 - 1044. [Abstract] [Full Text] [PDF]

				G. Cea, D. Bendahan, D. Manners, D. Hilton-Jones, R. Lodi, P. Styles, and D. J. Taylor Reduced oxidative phosphorylation and proton efflux suggest reduced capillary blood supply in skeletal muscle of patients with dermatomyositis and polymyositis: a quantitative 31P-magnetic resonance spectroscopy and MRI study Brain, July 1, 2002; 125(7): 1635 - 1645. [Abstract] [Full Text] [PDF]

				C. Haccoun, A. A. Smountas, W. J. Gibbons, J. Bourbeau, and L. C. Lands Isokinetic Muscle Function in COPD* Chest, April 1, 2002; 121(4): 1079 - 1084. [Abstract] [Full Text] [PDF]

				M. P. K. J. ENGELEN, E. F. M. WOUTERS, N. E. P. DEUTZ, J. D. DOES, and A. M. W. J. SCHOLS Effects of Exercise on Amino Acid Metabolism in Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., March 15, 2001; 163(4): 859 - 864. [Abstract] [Full Text]

				H. R Gosker, E. F. Wouters, G. J van der Vusse, and A. M. Schols Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure: underlying mechanisms and therapy perspectives Am. J. Clinical Nutrition, May 1, 2000; 71(5): 1033 - 1047. [Abstract] [Full Text] [PDF]

				E. F.M. Wouters Nutrition and Metabolism in COPD Chest, May 1, 2000; 117(5_suppl_1): 274S - 280S. [Full Text] [PDF]

				Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease . A Statement of the American Thoracic Society and European Respiratory Society Am. J. Respir. Crit. Care Med., April 1, 1999; 159(4): S2 - 40. [Full Text] [PDF]

				J. P. Mattson and D. C. Poole Pulmonary emphysema decreases hamster skeletal muscle oxidative enzyme capacity J Appl Physiol, July 1, 1998; 85(1): 210 - 214. [Abstract] [Full Text] [PDF]

				A. R. Shah, T. G. Keens, and D. Gozal Effect of supplemental oxygen on supramaximal exercise performance and recovery in cystic fibrosis J Appl Physiol, November 1, 1997; 83(5): 1641 - 1647. [Abstract] [Full Text] [PDF]