ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Order Full text via Infotrieve
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Semenzato, G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Semenzato, G
Eur Respir J 1991; 4: 94-102
Copyright © ERS Journals Ltd 1991

Original Articles

Immunology of interstitial lung diseases: cellular events taking place in the lung of sarcoidosis, hypersensitivity pneumonitis and HIV infection

G Semenzato

This paper summarizes our research and the results obtained on the topic of immunology of interstitial lung disorders. Areas of investigation mainly included sarcoidosis, hypersensitivity pneumonitis (HP), and more recently the pulmonary involvement in acquired immunodeficiency syndrome (AIDS). In sarcoidosis patients two major mechanisms account for the alveolitis, i.e. an in situ cellular proliferation and a cellular redistribution from the peripheral blood to the sites of disease activity, including the lung. These findings involve both lymphocytes (CD4 helper-related cells) and macrophages, and lead to the formation and provide maintenance of sarcoid granuloma. In patients with hypersensitivity pneumonitis the lung infiltrates are characterized by cells bearing suppressor/cytotoxic phenotype. The expansion of cells with these characteristics in the lung of these patients is likely to be related to a local immune response to the antigenic stimulus. In the lung of patients with AIDS we also found a discrete lymphocytic alveolitis bearing the CD8 cytotoxic-related phenotype. The role of cytotoxic events, related to the lymphocytes and macrophages, which are operative in the lung of AIDS patients, is being evaluated. The analysis of cells recovered from the lavage, mainly lymphocytes and macrophages, in terms of surface phenotype, functional in vitro evaluations and molecular analysis, has provided new insights into the pathogenesis of the above quoted interstitial lung disorders.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Barrera, F. Mendoza, J. Zuniga, A. Estrada, A. C. Zamora, E. I. Melendro, R. Ramirez, A. Pardo, and M. Selman
Functional Diversity of T-Cell Subpopulations in Subacute and Chronic Hypersensitivity Pneumonitis
Am. J. Respir. Crit. Care Med., January 1, 2008; 177(1): 44 - 55.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
J. M. Beck
The Immunocompromised Host: HIV Infection
Proceedings of the ATS, December 1, 2005; 2(5): 423 - 427.
[Abstract] [Full Text] [PDF]

Home page
 Sex. Transm. Infect.Home page
S Das and R F Miller
Lymphocytic interstitial pneumonitis in HIV infected adults
Sex Transm Inf, April 1, 2003; 79(2): 88 - 93.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Navarro, F. Mendoza, L. Barrera, L. Segura-Valdez, M. Gaxiola, I. Paramo, and M. Selman
Up-regulation of L-Selectin and E-Selectin in Hypersensitivity Pneumonitis
Chest, February 1, 2002; 121(2): 354 - 360.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. M. BECK, M. J. ROSEN, and H. H. PEAVY
Pulmonary Complications of HIV Infection . Report of the Fourth NHLBI Workshop
Am. J. Respir. Crit. Care Med., December 1, 2001; 164(11): 2120 - 2126.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. CAMARENA, A. JUAREZ, M. MEJIA, A. ESTRADA, G. CARRILLO, R. FALFAN, J. ZUNIGA, C. NAVARRO, J. GRANADOS, and M. SELMAN
Major Histocompatibility Complex and Tumor Necrosis Factor-{alpha} Polymorphisms in Pigeon Breeder's Disease
Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1528 - 1533.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. PARDO, R. BARRIOS, M. GAXIOLA, L. SEGURA-VALDEZ, G. CARRILLO, A. ESTRADA, M. MEJÍA, and M. SELMAN
Increase of Lung Neutrophils in Hypersensitivity Pneumonitis Is Associated with Lung Fibrosis
Am. J. Respir. Crit. Care Med., May 1, 2000; 161(5): 1698 - 1704.
[Abstract] [Full Text]

Home page
 ANN INTERN MEDHome page
P. T. Diaz, M. A. King, E. R. Pacht, M. D. Wewers, J. E. Gadek, H. N. Nagaraja, J. Drake, and T. L. Clanton
Increased Susceptibility to Pulmonary Emphysema among HIV-Seropositive Smokers
Ann Intern Med, March 7, 2000; 132(5): 369 - 372.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Israel-Assayag, M. Fournier, and Y. Cormier
Blockade of T Cell Costimulation by CTLA4-Ig Inhibits Lung Inflammation in Murine Hypersensitivity Pneumonitis
J. Immunol., December 15, 1999; 163(12): 6794 - 6799.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. ISRAËL-ASSAYAG, A. DAKHAMA, S. LAVIGNE, M. LAVIOLETTE, and Y. CORMIER
Expression of Costimulatory Molecules on Alveolar Macrophages in Hypersensitivity Pneumonitis
Am. J. Respir. Crit. Care Med., June 1, 1999; 159(6): 1830 - 1834.
[Abstract] [Full Text]

Home page
 NEJMHome page
L. S. Newman, C. S. Rose, and L. A. Maier
Sarcoidosis
N. Engl. J. Med., April 24, 1997; 336(17): 1224 - 1234.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by the European Respiratory Society.