HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Romieu, I. Articles by Sunyer, J. Search for Related Content PubMed PubMed Citation Articles by Romieu, I. Articles by Sunyer, J.

Air pollution, oxidative stress and dietary supplementation: a review

¹ Instituto Nacional de Salud Publica, Cuernavaca, Mexico, ² Instituto Municipal de Investigaciones Médicas, and ³ Institut Català de Recerca i Estudis Avançat (ICREA), Barcelona, Spain.

CORRESPONDENCE: I. Romieu, Instituto Nacional de Salud Publica, Av. Universidad No. 655, Col. Santa Maria Ahuacatitlan, Cuernavaca, Morelos 62508, Mexico. Fax: 52 7773111148. E-mail: iromieu{at}correo.insp.mx

Keywords: Air pollution, antioxidants, nutrition, oxidative stress

Received: October 2, 2006
Accepted August 20, 2007

The aim of the present review was to provide an up-to-date overview of the biological and epidemiological evidence of the role of oxidative stress as a major underlying feature of the toxic effect of air pollutants, and the potential role of dietary supplementation in enhancing antioxidant defences.

A bibliographic search was conducted through PubMed. The keywords used in the search were "air pollutant", "oxidative stress", "inflammation", "antioxidant polyunsaturated fatty acids" and "genetics". In addition, the authors also searched for biomarkers of oxidative stress and nutrients.

The review presents the most recent data on: the biological and epidemiological evidence of the oxidative stress response to air pollutants; the role of dietary supplementation as a modulator of these effects; and factors of inter-individual variation in human response. The methodology for further epidemiological studies will be discussed in order to improve the current understanding on how nutritional factors may act.

There is substantial evidence that air pollution exposure results in increased oxidative stress and that dietary supplementation may play a modulating role on the acute effect of air pollutants. Further epidemiological studies should address the impact of supplementation strategies in the prevention of air-pollution-related long-term effects in areas where people are destined to be exposed for the distant future.

This article has been cited by other articles:

				K. Marmsjo, H. Rosenlund, I. Kull, N. Hakansson, M. Wickman, G. Pershagen, and A. Bergstrom Use of multivitamin supplements in relation to allergic disease in 8-y-old children Am. J. Clinical Nutrition, December 1, 2009; 90(6): 1693 - 1698. [Abstract] [Full Text] [PDF]

				J. Sunyer Lung function effects of chronic exposure to air pollution Thorax, August 1, 2009; 64(8): 645 - 646. [Full Text] [PDF]

				A. Peters, S. Greven, I. M. Heid, F. Baldari, S. Breitner, T. Bellander, C. Chrysohoou, T. Illig, B. Jacquemin, W. Koenig, et al. Fibrinogen Genes Modify the Fibrinogen Response to Ambient Particulate Matter Am. J. Respir. Crit. Care Med., March 15, 2009; 179(6): 484 - 491. [Abstract] [Full Text] [PDF]

				J. Sunyer The neurological effects of air pollution in children Eur. Respir. J., September 1, 2008; 32(3): 535 - 537. [Full Text] [PDF]