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Computed tomographic screening for lung cancer: individualising the benefit of the screening

All International Early Lung Cancer Action Programme investigators are listed in the acknowledgements.

CORRESPONDENCE: C. I. Henschke, Dept of Radiology, New York Presbyterian Hospital–Weill Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA. Fax: 1 2127462811. E-mail: chensch{at}med.cornell.edu

Keywords: International Early Lung Cancer Action Program, lung cancer, survival

Received: January 2, 2007
Accepted July 12, 2007

Individuals concerned about their risk of lung cancer are recommended to talk with their physicians about computed tomographic screening for lung cancer. To provide the necessary information, the survival benefit of the screening, specific to a particular person for a particular round of screening, is needed.

The probability of survival gain from the first, baseline, round of screening was addressed as the product of: 1) the screening resulting in a diagnosis of lung cancer; 2) not dying from some other cause for a sufficiently long period of time; and 3) cure resulting from pre-symptomatic treatment of lung cancer. These probabilities were estimated using the International Early Lung Cancer Action Program data on individuals aged 40–85 yrs with a cigarette smoking history of 0–150 pack-yrs.

The estimated probability of survival gain ranged from 0.4% for a 60-yr-old with a 10-pack-yr smoking history who quit smoking 20 yrs ago, to 3.1% for a 70-yr-old current smoker with a 100 pack-yr history and 2.0% for an 85-yr-old current smoker with a 150-pack-yr history.

When seeking counsel about initiation of screening for lung cancer, an estimate of the probability of survival gain from the first round of computed tomographic screening, specific to the person's age and history of smoking, can be provided.

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