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Impact of blood transfusions on outcome after pneumonectomy for thoracic malignancies

¹ Faculty of Medicine, Université de la Méditerranée, and Depts of ² Thoracic Surgery, ³ Anaesthesia and Intensive Care, ⁴ Thoracic Oncology, and ⁵ Medical Information and Statistics, Sainte Marguerite Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.

CORRESPONDENCE: P. Thomas, Dept of Thoracic Surgery, Sainte Marguerite Hospital- CHU Sud, 270 Bd Ste Marguerite, 13274 Marseille Cedex 9, France. Fax: 33 491744590. E-mail: Pascal-alexandre.Thomas{at}mail.ap-hm.fr

Keywords: Outcomes, surgical management, survival analysis, thoracic malignancies

Received: May 4, 2006
Accepted October 21, 2006

The aim of the present study was to determine the risk factors and impact on outcome of blood transfusions following pneumonectomy for thoracic malignancies.

A retrospective analysis of 432 consecutive patients was carried out, of whom 183 (42.4%) were transfused post-operatively. The associations between blood transfusions and 20 variables were assessed by univariate and multivariate analysis. Survival analysis included log-rank test and Cox regression model.

Patient age, neoadjuvant treatment, completion pneumonectomy and extended procedures were independent predictors of transfusion. It was found that 30-day mortality increased significantly from 2.4% (no transfusion) to 10.9 and 21.9% (2 and >2 red blood cell packs, respectively). Blood transfusion was the strongest predictor of 30-day mortality (odds ratio (OR) 10; 95% confidence interval (CI): 3.7–27), respiratory failure (OR 19.2; 95% CI 7.4–49.4) and infectious complications (OR 3; 95% CI 1.5–6.2). In the 367 lung cancer patients, a significantly lower 5-yr survival was observed in univariate analysis of transfused patients (27.8±5.4% versus 39.4±4.5%). In a Cox regression analysis, blood transfusion was no longer found to be significant.

A dose-related correlation is suggested between blood transfusion and early mortality through an increase of infectious and respiratory complications. In contrast, blood transfusion had no independent adverse impact on long-term survival.

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