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Eur Respir J 2007; 29:418-422
Copyright ©ERS Journals Ltd 2007
doi: 10.1183/09031936.00076406

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Detecting cardiac involvement in sarcoidosis: a call for prospective studies of newer imaging techniques

C. Pandya1, R. C. Brunken2,3, P. Tchou3, P. Schoenhagen3,4 and D. A. Culver1,5

Depts of 1 Pulmonary, Allergy and Critical Care Medicine, 2 Molecular and Functional Imaging, 3 Cardiovascular Medicine, 4 Diagnostic Radiology, and 5 Pathobiology, The Cleveland Clinic, Cleveland, OH, USA.

CORRESPONDENCE: D. A. Culver, Dept of Pulmonary, Allergy and Critical Care Medicine, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Fax: 1 2164458160. E-mail: culverd{at}ccf.org

Keywords: Cardiac arrhythmias, granulomatosis, imaging, magnetic resonance imaging, positron emission tomography, sarcoidosis

Received: June 12, 2006
Accepted October 9, 2006

Diagnosis of cardiac involvement in sarcoidosis is challenging and usually relies on a combination of clinical findings and imaging abnormalities.

The case of a 53-yr-old female is described who presented with ventricular tachycardia and suspected angiosarcoma involving the right atrium and superior vena cava.

A combination of magnetic resonance imaging and 18F-2-fluoro-2-deoxyglucose-positron emission tomography were essential to the diagnosis of cardiac sarcoidosis.

Reversibility of the disease was predicted more clearly by 18F-2-fluoro-2-deoxyglucose-positron emission tomography than by magnetic resonance imaging, and clinical activity was predicted by persistent hypermetabolism on serial 18F-2-fluoro-2-deoxyglucose-positron emission tomography.




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