HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (12) Citing Articles via Google Scholar Google Scholar Articles by Gan, C. T. Articles by Vonk-Noordegraaf, A. Search for Related Content PubMed PubMed Citation Articles by Gan, C. T. Articles by Vonk-Noordegraaf, A.

NT-proBNP reflects right ventricular structure and function in pulmonary hypertension

¹ Depts of Pulmonary Diseases, ³ Physics and Medical Technology, and, ⁴ Clinical Epidemiology and Biostatistics, Institute for Cardiovascular Research ICaR-VU, VU University Medical Centre Amsterdam, The Netherlands, and ² Dept of Cardiology, University Hospitals Leicester, NHS Trust, Leicester, UK.

CORRESPONDENCE: A. Vonk-Noordegraaf, Dept of Pulmonary diseases, VU University Medical Centre, De Boelelaan 1117, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. Fax: 31 204444328. E-mail: a.vonk{at}vumc.nl

Keywords: Magnetic resonance imaging, N-terminal pro brain natriuretic peptide, pulmonary hypertension, right ventricle

Received: February 2, 2006
Accepted August 14, 2006

The aim of the current study was to investigate whether alterations in N-terminal pro brain natriuretic peptide (NT-proBNP) reflect changes in right ventricular structure and function in pulmonary hypertension patients during treatment.

The study consisted of 30 pulmonary hypertension patients; 15 newly diagnosed and 15 on long-term treatment. NT-proBNP, right heart catheterisation and cardiac magnetic resonance imaging measurements were performed, at baseline and follow-up.

There were no significant differences between newly diagnosed patients and those on treatment at baseline or follow-up with respect to NT-proBNP, haemodynamics and right ventricular parameters. Relative changes in NT-proBNP during treatment were correlated to the relative changes in right ventricular end-diastolic volume index (r = 0.59), right ventricular mass index (r = 0.62) and right ventricular ejection fraction (r = –0.81).

N-terminal pro brain natriuretic peptide measurements reflect changes in magnetic resonance imaging-measured right ventricular structure and function in pulmonary hypertension patients. An increase in N-terminal pro brain natriuretic peptide over time reflects right ventricular dilatation concomitant to hypertrophy and deterioration of systolic function.

This article has been cited by other articles:

				V. V. McLaughlin, D. B. Badesch, M. Delcroix, T. R. Fleming, S. P. Gaine, N. Galie, J. S. R. Gibbs, N. H. Kim, R. J. Oudiz, A. Peacock, et al. End Points and Clinical Trial Design in Pulmonary Arterial Hypertension J. Am. Coll. Cardiol., June 30, 2009; 54(1_Suppl_S): S97 - S107. [Abstract] [Full Text] [PDF]

				L. E. R. McLure and A. J. Peacock Cardiac magnetic resonance imaging for the assessment of the heart and pulmonary circulation in pulmonary hypertension Eur. Respir. J., June 1, 2009; 33(6): 1454 - 1466. [Abstract] [Full Text] [PDF]

				I. R. Henkens, C. T.-J. Gan, S. A. van Wolferen, M. Hew, A. Boonstra, J. W. R. Twisk, O. Kamp, E. E. van der Wall, M. J. Schalij, A. Vonk Noordegraaf, et al. ECG Monitoring of Treatment Response in Pulmonary Arterial Hypertension Patients Chest, December 1, 2008; 134(6): 1250 - 1257. [Abstract] [Full Text] [PDF]

				J. Suntharalingam, C. M. Treacy, N. J. Doughty, K. Goldsmith, E. Soon, M. R. Toshner, K. K. Sheares, R. Hughes, N. W. Morrell, and J. Pepke-Zaba Long-term Use of Sildenafil in Inoperable Chronic Thromboembolic Pulmonary Hypertension Chest, August 1, 2008; 134(2): 229 - 236. [Abstract] [Full Text] [PDF]

				M. J. Overbeek, G. P. van Nieuw Amerongen, A. Boonstra, E. F. Smit, and A. Vonk-Noordegraaf Possible role of imatinib in clinical pulmonary veno-occlusive disease Eur. Respir. J., July 1, 2008; 32(1): 232 - 235. [Abstract] [Full Text] [PDF]

				J. Behr and J. H. Ryu Pulmonary hypertension in interstitial lung disease Eur. Respir. J., June 1, 2008; 31(6): 1357 - 1367. [Abstract] [Full Text] [PDF]

				A. Fijalkowska and A. Torbicki Role of cardiac biomarkers in assessment of RV function and prognosis in chronic pulmonary hypertension Eur. Heart J. Suppl., December 1, 2007; 9(suppl_H): H41 - H47. [Abstract] [Full Text] [PDF]

				S. A. van Wolferen, J. T. Marcus, A. Boonstra, K. M.J. Marques, J. G.F. Bronzwaer, M. D. Spreeuwenberg, P. E. Postmus, and A. Vonk-Noordegraaf Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension Eur. Heart J., May 2, 2007; 28(10): 1250 - 1257. [Abstract] [Full Text] [PDF]

				A. Vonk Noordegraaf and N. Westerhof Right ventricular ejection fraction and NT-proBNP are both indicators of wall stress in pulmonary hypertension Eur. Respir. J., April 1, 2007; 29(4): 622 - 623. [Full Text] [PDF]