|
 |
|
|||||||
|
|||||||||
Copyright ©ERS Journals Ltd 2006
COPD is associated with increased mortality in patients with community-acquired pneumonia
1 The Veterans Evidence-based Research, Dissemination, and Implementation Center, Audie L Murphy Veterans Hospital, and, Divisions of 2 General Medicine, and 3 Pulmonary and Critical Care Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
CORRESPONDENCE: M. I. Restrepo, VERDICT (11C6) at the South Texas Veterans Health Care System, Audie L. Murphy Division at San Antonio, 7400 Merton Minter Boulevard, San Antonio TX, 78284, USA. Fax: 1 2105674423. E-mail: restrepom{at}uthscsa.edu
Keywords: Chronic obstructive pulmonary disease, community-acquired pneumonia, mortality
Received: November 10, 2005
Accepted April 7, 2006
Patients with chronic obstructive pulmonary disease (COPD) who develop community-acquired pneumonia (CAP) may experience worse clinical outcomes. However, COPD is not included as a distinct diagnosis in validated instruments that predict mortality in patients with CAP. The aim of the present study was to evaluate the impact of COPD as a comorbid condition on 30- and 90-day mortality in CAP patients. A retrospective observational study was conducted at two hospitals. Eligible patients had a discharge diagnosis and radiological confirmation of CAP.
Among 744 patients with CAP, 215 had a comorbid diagnosis of COPD and 529 did not have COPD. The COPD group had a higher mean pneumonia severity index score (105±32 versus 87±34) and were admitted to the intensive care unit more frequently (25 versus 18%). After adjusting for severity of disease and processes of care, CAP patients with COPD showed significantly higher 30- and 90-day mortality than non-COPD patients.
Chronic obstructive pulmonary disease patients hospitalised with community-acquired pneumonia exhibited higher 30- and 90-day mortality than patients without chronic obstructive pulmonary disease. Chronic obstructive pulmonary disease should be evaluated for inclusion in community-acquired pneumonia prediction instruments.
This article has been cited by other articles:
|
|
 |
|
  S. Singh, A. V. Amin, and Y. K. Loke Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease: A Meta-analysis Arch Intern Med, February 9, 2009; 169(3): 219 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Drummond, E. C. Dasenbrook, M. W. Pitz, D. J. Murphy, and E. Fan Inhaled Corticosteroids in Patients With Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis JAMA, November 26, 2008; 300(20): 2407 - 2416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Marriott, L. E. Jackson, T. S. Wilkinson, A. J. Simpson, T. J. Mitchell, D. J. Buttle, S. S. Cross, P. G. Ince, P. G. Hellewell, M. K. B. Whyte, et al. Reactive Oxygen Species Regulate Neutrophil Recruitment and Survival in Pneumococcal Pneumonia Am. J. Respir. Crit. Care Med., April 15, 2008; 177(8): 887 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Restrepo, E. M. Mortensen, J. A. Velez, C. Frei, and A. Anzueto A Comparative Study of Community-Acquired Pneumonia Patients Admitted to the Ward and the ICU Chest, March 1, 2008; 133(3): 610 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Garcia-Vidal, E. Calbo, V. Pascual, C. Ferrer, S. Quintana, and J. Garau Effects of systemic steroids in patients with severe community-acquired pneumonia Eur. Respir. J., November 1, 2007; 30(5): 951 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Menendez and A. Torres Treatment Failure in Community-Acquired Pneumonia Chest, October 1, 2007; 132(4): 1348 - 1355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Torres and R. Menendez Mortality in COPD patients with community-acquired pneumonia: who is the third partner? Eur. Respir. J., August 1, 2006; 28(2): 262 - 263. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |