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Cough: what's in a name?

¹ University of London, London, UK, and ² Sezione di Medicina Respiratoria, Universita dQi Firenze, Florence, Italy.

CORRESPONDENCE: J. G. Widdicombe, 116 Pepys Road, London SW20 8NY, UK, Fax: 44 2082861815. E-mail: JohnWiddicombeJ{at}aol.com

Keywords: cough, expiration reflex, larynx, trachea, bronchi

Received: August 19, 2005
Accepted February 8, 2006

The cough reflex (CR) and the expiration reflex (ER) are two defensive reflexes from the respiratory tract, the latter mainly from the larynx. Both are elicited by mechanical and chemical irritation of the airway mucosa, and are a characteristic of airway diseases, but they have different functions. The CR first draws air into the lungs, to accentuate the subsequent expulsive phase; the ER consists of a strong expiration, to prevent aspiration of material into the lungs. They have different sensory pathways, central nervous circuits, and physiological and pharmacological modulations. In practice, coughing often consists of a combination of the two reflexes, a cough bout, epoch or attack. Articles on cough usually do not distinguish between the two reflexes, or whether the coughs are single events or epochs; they usually only measure frequency of expiratory efforts, and neglect other aspects. Current methods for measuring and assessing cough are described, with indications of when the use of these methods may be important.

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