HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Wewel, A. R. Articles by Holz, O. Search for Related Content PubMed PubMed Citation Articles by Wewel, A. R. Articles by Holz, O.

Time course of exhaled hydrogen peroxide and nitric oxide during chemotherapy

¹ Hospital Großhansdorf, Center for Pneumology and Thoracic Surgery, Großhansdorf, ² FILT, Berlin, ³ Institute and Outpatient Clinic for Occupational and Environmental Medicine, Ludwig-Maximilians University, Munich, and ⁴ University of Lüneburg, Environmental Chemistry, Lüneburg, Germany.

CORRESPONDENCE: O. Holz, Research Laboratory, Hospital Großhansdorf, Center for Pneumology and Thoracic Surgery, Wöhrendamm 80, D-22927 Großhansdorf, Germany. Fax: 49 4102692295. E-mail: o.holz{at}pulmoresearch.de

Keywords: Carboplatin, cisplatin, exhaled breath condensate, neutrophils, peripheral blood

Received: September 1, 2005
Accepted December 23, 2005

This study was designed to assess the effect of differential leukocyte depletion during chemotherapy by monitoring the levels of exhaled hydrogen peroxide H₂O₂ and nitric oxide (F_eNO) present.

In 39 patients with lung cancer (chronic obstructive pulmonary disorder up to stage II, median forced expiratory volume in one second 78% predicted), measurements were performed before a cycle of therapy (day 1), at least once during the cycle (day 8: n = 34; day 15: n = 19), and afterwards (days 21–29).

There were significant changes in the level of H₂O₂, F_eNO and peripheral blood cell differentials over the visits. The level of H₂O₂ was decreased only on day 15, with a median (difference between the upper and lower quartiles) fall of 31 (57)%, while F_eNO was reduced only on day 8, by 22 (40)%. Neutrophil numbers were unchanged on day 8 and decreased by 59 (48)% on day 15, while monocyte numbers were decreased on day 8 by 87 (39)%. On days 21–29, values had returned to baseline.

Taken together with previous findings, the parallel course of levels of exhaled hydrogen peroxide and neutrophil counts suggests that a major part of exhaled hydrogen peroxide is due to neutrophils via the conducting airways. In contrast, the production of exhaled nitric oxide seems to be primarily associated with monocytes.

This article has been cited by other articles:

				I. Horvath, Z. Lazar, N. Gyulai, M. Kollai, and G. Losonczy Exhaled biomarkers in lung cancer Eur. Respir. J., July 1, 2009; 34(1): 261 - 275. [Abstract] [Full Text] [PDF]