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Copyright ©ERS Journals Ltd 2005
The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy
1 Division of Allergy and Clinical Immunology, The Johns Hopkins University, and 2 National Institute of Aging, National Institutes of Health (NIH), Baltimore, MD, and 3 Dept of Surgery, Molecular Microbiology and Immunology, University of Missouri-Columbia, Columbia, MO, USA.
CORRESPONDENCE: C. Stellato, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. Fax: 1 4105502130. E-mail: stellato{at}jhmi.edu
Keywords: Allergy, chemokines, inflammation, post-transcriptional regulation, RNA stability
Received: October 21, 2004
Accepted June 28, 2005
The aim of this review is to discuss recent advances in the understanding of the regulation of chemokine expression occurring during chronic inflammatory conditions, such as allergic diseases. The focus will be on current data, which suggest that post-transcriptional regulation plays a larger role in chemokine gene regulation than previously recognised. In particular, a growing body of data indicates that mechanisms controlling mRNA stability may be relevant in determining, or maintaining, the increased levels of chemokine gene expression in this context. Such regulatory pathways may be important targets of novel anti-inflammatory strategies.
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