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Adaptation of the diaphragm and the vastus lateralis in mild-to-moderate COPD

¹ Centre de Recherche de l'Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Université Laval, ² Division de Kinésiologie, Université Laval, and ³ Centre de Recherche du CHUQ Pavillon CHUL, Université Laval, Québec, Canada

CORRESPONDENCE: F. Maltais, Centre de Pneumologie, 2725 Chemin Ste-Foy, Ste-Foy, Québec, G1V 4G5, Canada. Fax: 1 4186564762. E-mail: medfma@hermes.ulaval.ca

Keywords: Adaptation, chronic obstructive pulmonary disease, diaphragm, vastus lateralis

Received: April 16, 2004
Accepted July 30, 2004

This study was supported by Canadian Institutes of Health Research grant MOP-53135. R. Debigaré was the recipient of a PhD training award from the Fonds de la Recherche en Santé du Québec. F. Maltais is a research scholar of the Fonds de la Recherche en Santé du Québec.

The chronology of diaphragm and vastus lateralis adaptation in chronic obstructive pulmonary disease (COPD) has not been studied. The hypothesis of this study was that muscle changes would occur earlier in the diaphragm than in the vastus lateralis in COPD, a finding that would suggest that local factors would be more important than systemic factors in determining the muscle phenotypic expression, at least in mild-to-moderate disease.

The adaptation of the vastus lateralis and diaphragm muscles was evaluated in patients with mild-to-moderate COPD and in subjects with normal pulmonary function.

In both groups, the oxidative potential and the number of lipofuscin inclusions were higher in the diaphragm than in the vastus lateralis. Compared to control, the diaphragm in COPD had a higher oxidative capacity and a higher proportion of type I fibres, with a reciprocal decrease in type IIA fibres, while there was no difference in diaphragmatic cross sectional areas, capillarisation and lipofuscin inclusions. No significant differences were found in the vastus lateralis from both groups.

In conclusion, these data indicate that the diaphragm in controls and in chronic obstructive pulmonary disease has a higher oxidative potential than the vastus lateralis, and that muscle adaptation occurs earlier in the diaphragm than in the vastus lateralis in mild-to-moderate chronic obstructive pulmonary disease.

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