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Differential effects of emphysema on skeletal muscle fibre atrophy in hamsters

¹ College of Health, University of Utah, Salt Lake City, UT, ² Depts of Health and Kinesiology and Medical Physiology, and the Cardiovascular Research Institute, Texas A&M University, College Station, TX, and ³ Depts of Anatomy, Physiology and Kinesiology, Kansas State University, Manhattan, USA

CORRESPONDENCE: J.P. Mattson, 1850 East 250 South, Room 241, College of Health, University of Utah, Salt Lake City, 84112-0920, USA. Fax: 1 8015853992. E-mail: jmattson@hsc.utah.edu

Keywords: Chronic obstructive pulmonary disease, muscle composition, muscle fibre cross-sectional area

Received: September 15, 2003
Accepted January 8, 2004

This study was supported by USA Public Health Service Grant HL-50306 from the National Institutes of Health and American Lung Grant RG-013-N.

Patients afflicted with emphysema demonstrate altered peripheral skeletal muscle fibre composition and atrophy. It is unknown whether these alterations are general to all skeletal muscles independent of function, phenotype or oxidative capacity. Therefore, the purpose of this investigation was to determine whether emphysema induces alterations in muscle fibre composition or atrophy in respiratory and locomotory muscles with diverse fibre types and metabolic profiles.

Fibre composition and cross-sectional area were measured in selected hindlimb muscles and diaphragm of hamsters following saline (control, n=7) or elastase (emphysema, n=15) instillation.

Excised lung volume increased 145% with emphysema. Fibre composition was largely unaltered, with the exception of a 13% reduction in IIB fibres in the tibialis anterior muscle of emphysema animals. Type I fibre size was also mainly unaltered, except for a diminished cross-sectional area in plantaris muscle. However, fibre cross-sectional area of fast-twitch types IIA, IIX and/or IIB fibres was reduced in the caudal biceps femoris, vastus lateralis, tibialis anterior, gastrocnemius and plantaris muscles of emphysema animals. In contrast, there was a trend for emphysema to increase the cross-sectional area of type IIA fibres in the diaphragm.

These data demonstrate that emphysema-induced atrophy primarily affects locomotory muscles, independent of phenotype or oxidative capacity.

This article has been cited by other articles:

				J. P Mattson and J. C Martin Emphysema-induced reductions in locomotory skeletal muscle contractile function Exp Physiol, July 1, 2005; 90(4): 519 - 525. [Abstract] [Full Text] [PDF]