ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (19)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miotto, D.
Right arrow Articles by Mapp, C.E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miotto, D.
Right arrow Articles by Mapp, C.E.
Eur Respir J 2003; 22:602-608
Copyright ©ERS Journals Ltd 2003

Interleukin-13 and -4 expression in the central airways of smokers with chronic bronchitis

D. Miotto1, M.P. Ruggieri2, P. Boschetto1, G. Cavallesco3, A. Papi1, I. Bononi1, C. Piola2, B. Murer4, L.M. Fabbri2 and C.E. Mapp1

1 Dept of Clinical and Experimental Medicine, University of Ferrara, Ferrara, 2 Dept of Medicine, Oncology and Radiology, University of Modena and Reggio Emilia, Modena, 3 Dept of Surgery, Anesthesiology and Radiology, University of Ferrara, Ferrara, and 4 Dept of Pathology, General Hospital of Mestre, Mestre, Italy

CORRESPONDENCE: C.E. Mapp, Dipartimento di Medicina Clinica e Sperimentale, Sezione di Igiene e Medicina del Lavoro, Via Fossato da Mortara 64/b, 44100, Ferrara, Italy. Fax: 39 0532205066. E-mail: map@dns.unife.it

Keywords: chronic bronchitis, cytokines, mucus hypersecretion

Received: May 30, 2002
Accepted June 6, 2003

This work was supported by the MURST (Minister of University and Scientific Research, Italy; 60%, 40%), ARCA (Associazione per la Ricerca e la Cura dell'Asma, Padova, Italy) and Ferrararicerche (Ferrara, Italy).

The aim of this study was to determine whether the T-helper 2-type cytokines interleukin (IL)-13 and -4 are involved in mucus hypersecretion, the hallmark of chronic bronchitis (CB).

Surgical specimens were examined from 33 subjects undergoing lung resection for localised peripheral malignant pulmonary lesions: 21 smokers with symptoms of CB, 10 asymptomatic smokers (AS) and two nonsmokers with normal lung function. The number of IL-4 and -13 positive (+) cells in the central airways was quantified. To better assess the cytokine profile, a count was also made of IL-5+ and interferon (IFN)-{gamma}+ cells.

Compared to AS, the CB group had an increased number of IL-13+ and -4+ cells in the bronchial submucosa, while the number of IL-5+ and IFN-{gamma}+ cells were similar in all the groups. No significant associations were found between the number of cells expressing IL-13 or -4 and the number of inflammatory cells. Double labelling showed that 13.2 and 12.9% of IL-13+ cells were also CD8+ and CD4+, whereas 7.5 and 5% of IL-4+ cells were CD8+ and CD4+, respectively.

In conclusion, T-helper-2 and -1 protein expression is present in the central airways of smokers and interleukin-4 and -13 could contribute to mucus hypersecretion in chronic bronchitis.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
G. Turato, A. Barbato, S. Baraldo, M. E. Zanin, E. Bazzan, K. Lokar-Oliani, F. Calabrese, C. Panizzolo, D. Snijders, P. Maestrelli, et al.
Nonatopic Children with Multitrigger Wheezing Have Airway Pathology Comparable to Atopic Asthma
Am. J. Respir. Crit. Care Med., September 1, 2008; 178(5): 476 - 482.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Ying, B. O'Connor, J. Ratoff, Q. Meng, C. Fang, D. Cousins, G. Zhang, S. Gu, Z. Gao, B. Shamji, et al.
Expression and Cellular Provenance of Thymic Stromal Lymphopoietin and Chemokines in Patients with Severe Asthma and Chronic Obstructive Pulmonary Disease
J. Immunol., August 15, 2008; 181(4): 2790 - 2798.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. F. Chung and I. M. Adcock
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
Eur. Respir. J., June 1, 2008; 31(6): 1334 - 1356.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H. Imaoka, T. Hoshino, S. Takei, T. Kinoshita, M. Okamoto, T. Kawayama, S. Kato, H. Iwasaki, K. Watanabe, and H. Aizawa
Interleukin-18 production and pulmonary function in COPD
Eur. Respir. J., February 1, 2008; 31(2): 287 - 297.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. B. Snoeck-Stroband, T. S. Lapperre, M. M. E. Gosman, H. M. Boezen, W. Timens, N. H. T. ten Hacken, J. K. Sont, P. J. Sterk, P. S. Hiemstra, and the Groningen Leiden Universities Corticosteroids
Chronic bronchitis sub-phenotype within COPD: inflammation in sputum and biopsies
Eur. Respir. J., January 1, 2008; 31(1): 70 - 77.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
T. Yamagata, H. Sugiura, T. Yokoyama, S. Yanagisawa, T. Ichikawa, K. Ueshima, K. Akamatsu, T. Hirano, M. Nakanishi, Y. Yamagata, et al.
Overexpression of CD-11b and CXCR1 on Circulating Neutrophils: Its Possible Role in COPD
Chest, September 1, 2007; 132(3): 890 - 899.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Zhang, L. Shan, M. S. Rahman, H. Unruh, A. J. Halayko, and A. S. Gounni
Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease
Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L375 - L382.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. E. Hegab, T. Sakamoto, A. Nomura, Y. Ishii, Y. Morishima, T. Iizuka, T. Kiwamoto, Y. Matsuno, S. Homma, and K. Sekizawa
Niflumic Acid and AG-1478 Reduce Cigarette Smoke-Induced Mucin Synthesis: The Role of hCLCA1
Chest, April 1, 2007; 131(4): 1149 - 1156.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M.-J. Kang, R. J. Homer, A. Gallo, C. G. Lee, K. A. Crothers, S. J. Cho, C. Rochester, H. Cain, G. Chupp, H. J. Yoon, et al.
IL-18 Is Induced and IL-18 Receptor {alpha} Plays a Critical Role in the Pathogenesis of Cigarette Smoke-Induced Pulmonary Emphysema and Inflammation
J. Immunol., February 1, 2007; 178(3): 1948 - 1959.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. J. Holtzman, J. T. Battaile, and A. C. Patel
Immunogenetic Programs for Viral Induction of Mucous Cell Metaplasia
Am. J. Respir. Cell Mol. Biol., July 1, 2006; 35(1): 29 - 39.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Bruno, P. Chanez, G. Chiappara, L. Siena, S. Giammanco, M. Gjomarkaj, G. Bonsignore, J. Bousquet, and A. M. Vignola
Does leptin play a cytokine-like role within the airways of COPD patients?
Eur. Respir. J., September 1, 2005; 26(3): 398 - 405.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
B. Bartalesi, E. Cavarra, S. Fineschi, M. Lucattelli, B. Lunghi, P. A. Martorana, and G. Lungarella
Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants
Eur. Respir. J., January 1, 2005; 25(1): 15 - 22.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
D. Miotto, P. Boschetto, I. Bononi, E. Zeni, G. Cavallesco, L.M. Fabbri, and C.E. Mapp
Vasoactive intestinal peptide receptors in the airways of smokers with chronic bronchitis
Eur. Respir. J., December 1, 2004; 24(6): 958 - 963.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. E. Hegab, T. Sakamoto, W. Saitoh, H. H. Massoud, H. M. Massoud, K. M. Hassanein, and K. Sekizawa
Polymorphisms of IL4, IL13, and ADRB2 Genes in COPD
Chest, December 1, 2004; 126(6): 1832 - 1839.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
P. J. Barnes
Mediators of Chronic Obstructive Pulmonary Disease
Pharmacol. Rev., December 1, 2004; 56(4): 515 - 548.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the European Respiratory Society.