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1 Dept of Clinical and Experimental Medicine, University of Ferrara, Ferrara, 2 Dept of Medicine, Oncology and Radiology, University of Modena and Reggio Emilia, Modena, 3 Dept of Surgery, Anesthesiology and Radiology, University of Ferrara, Ferrara, and 4 Dept of Pathology, General Hospital of Mestre, Mestre, Italy
CORRESPONDENCE: C.E. Mapp, Dipartimento di Medicina Clinica e Sperimentale, Sezione di Igiene e Medicina del Lavoro, Via Fossato da Mortara 64/b, 44100, Ferrara, Italy. Fax: 39 0532205066. E-mail: map@dns.unife.it
Keywords: chronic bronchitis, cytokines, mucus hypersecretion
Received: May 30, 2002
Accepted June 6, 2003
This work was supported by the MURST (Minister of University and Scientific Research, Italy; 60%, 40%), ARCA (Associazione per la Ricerca e la Cura dell'Asma, Padova, Italy) and Ferrararicerche (Ferrara, Italy).
The aim of this study was to determine whether the T-helper 2-type cytokines interleukin (IL)-13 and -4 are involved in mucus hypersecretion, the hallmark of chronic bronchitis (CB).
Surgical specimens were examined from 33 subjects undergoing lung resection for localised peripheral malignant pulmonary lesions: 21 smokers with symptoms of CB, 10 asymptomatic smokers (AS) and two nonsmokers with normal lung function. The number of IL-4 and -13 positive (+) cells in the central airways was quantified. To better assess the cytokine profile, a count was also made of IL-5+ and interferon (IFN)-
Compared to AS, the CB group had an increased number of IL-13+ and -4+ cells in the bronchial submucosa, while the number of IL-5+ and IFN-
In conclusion, T-helper-2 and -1 protein expression is present in the central airways of smokers and interleukin-4 and -13 could contribute to mucus hypersecretion in chronic bronchitis.
+ cells. + cells were similar in all the groups. No significant associations were found between the number of cells expressing IL-13 or -4 and the number of inflammatory cells. Double labelling showed that 13.2 and 12.9% of IL-13+ cells were also CD8+ and CD4+, whereas 7.5 and 5% of IL-4+ cells were CD8+ and CD4+, respectively.
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