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Primary pulmonary hypertension, Castleman's disease and human herpesvirus-8

¹ Dept of Medicine, Division of Pulmonaryand Critical Care Medicine, Pulmonary Hypertension Center, ² Dept of Pathology and ³ Division of Infectious Disease, University of Colorado Health Sciences Center, Denver, CO, USA

CORRESPONDENCE: T.M. Bull, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Box C-272, 4200 East Ninth Ave, Denver, CO, 80262, USA. Fax: 1 3033155632. E-mail: Todd.Bull@uchsc.edu

Keywords: endothelial cell, human herpesvirus-8, plexiform lesion, primary pulmonary hypertension

Received: January 19, 2003
Accepted April 17, 2003

Abstract

Primary pulmonary hypertension (PPH) and Castleman's disease (CD) are rare conditions infrequently encountered in clinical practice.

In this paper, two patients diagnosed with both of these diseases are reported. The authors speculate that rather than being a chance occurrence, these conditions are linked by a common angio-proliferative mechanism. Therefore, an association between infection with the human herpesvirus-8 and the diseases of PPH and CD was sought.

Evidence of human herpesvirus-8 infection was found in the lung tissue and, specifically, in the plexiform lesions from one of the patients.

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