HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Verleden, G.M. Articles by Demedts, M. Search for Related Content PubMed PubMed Citation Articles by Verleden, G.M. Articles by Demedts, M.

Exhaled nitric oxide after lung transplantation: impact of the native lung

Depts of ¹ Respiratory Diseases, ² Cardiology, ³ Thoracic Surgery and ⁴ Lung Transplantation, University Hospital Gasthuisberg, Leuven, Belgium

CORRESPONDENCE: G.M. Verleden, Dept Respiratory Disease and Lung Transplantation Unit, University Hospital Gasthuisberg, 49 Herestraat, B-3000, Leuven, Belgium. Fax: 32 16346803. E-mail: geert.verleden@uz.kuleuven.ac.be

Keywords: exhaled nitric oxide, lung transplantation, obliterative bronchiolitis

Received: March 21, 2002
Accepted October 18, 2002

It has already been demonstrated that exhaled nitric oxide (eNO) is increased in lung transplant patients with chronic rejection, although it is not known whether the diseased native lung after single lung transplantation (SLTx) contributes to the increased eNO values. This study aimed to compare the eNO values in stable lung transplant patients (SLTx versus sequential (S)SLTx and heart (H)LTx) and in patients with established chronic rejection.

Altogether, 42 LTx patients (25 females, 13 SLTx, 18 SSLTx, 11 HLTx), with a mean follow­up of 1149 days and a mean age of 44.6 yrs at transplantation, were included. Twenty­six patients had no signs of chronic rejection (five SLTx and 21 SSLTx/HLTx). There was no difference in their eNO values (10.2 in SLTx versus 12.2 (parts per billion) ppb in SSLTx/HLTx). Sixteen patients (eight SLTx and eight SSLTx/HLTx) had a chronic rejection (eight bronchiolitis obliterans syndrome (BOS) potential stage, four BOS stage 1, three BOS stage 2 and one BOS stage 3). Their eNOs were 18.1 (SLTx) and 17.0 (SSLTx/HLTx) ppb, respectively, which were significantly different to the stable LTx patients and showed a trend towards significance for SSLTx/HLTx. There was no significant difference in eNO between the patients with chronic rejection who underwent SLTx and those who underwent SSLTx/HLTx.

The diseased native lung after single lung transplantation probably does not contribute much to the exhaled nitric oxide values, either in stable lung transplant patients or in lung transplant patients with chronic rejection.

This article has been cited by other articles:

				J. Choi, L. A. Hoffman, G. W. Rodway, and J. M. Sethi Markers of lung disease in exhaled breath: nitric oxide. Biol Res Nurs, April 1, 2006; 7(4): 241 - 255. [Abstract] [PDF]

				O. Brugiere, G. Thabut, H. Mal, A. Marceau, G. Dauriat, R. Marrash-Chahla, Y. Castier, G. Leseche, M. Colombat, and M. Fournier Exhaled NO may predict the decline in lung function in bronchiolitis obliterans syndrome Eur. Respir. J., May 1, 2005; 25(5): 813 - 819. [Abstract] [Full Text] [PDF]