HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (36) Citing Articles via Google Scholar Google Scholar Articles by Marcos, M.A. Articles by Torres, A. Search for Related Content PubMed PubMed Citation Articles by Marcos, M.A. Articles by Torres, A.

Rapid urinary antigen test for diagnosis of pneumococcal community-acquired pneumonia in adults

¹ Dept of Microbiology and ² Dept of Infectious Diseases, Institute of Infections and Immunology, and ³ Dept of Pneumology, Institute of Pneumology and Thoracic Surgery, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain

CORRESPONDENCE: A. Torres, Institute of Pneumology and Thoracic Surgery, Hospital Clínic Universitari, C/Villarroel 170, 08036, Barcelona, Spain. Fax: 34 932279813. E-mail: atorres@medicina.ub.es

Keywords: community-acquired pneumonia, rapid diagnosis, Streptococcus pneumoniae, urinary antigen

Received: July 5, 2002
Accepted October 25, 2002

This work was supported by grants from the following: Sociedad Española de Neumología y Cirugía Torácica (SEPAR), Spanish Ministry of Health (FIS 00/0505), FUCAP (Maria Ravá), and Binax Inc (Portland, ME, USA).

Streptococcus pneumoniae is suspected to cause an important proportion of community-acquired pneumonia (CAP) whose aetiology cannot be detected with conventional tests.

In this study, the authors evaluated the diagnostic yield of a new immunochromatographic membrane test (ICT) for the detection of the S. pneumoniae antigen in the urine of patients admitted with diagnosed CAP. ICT was performed in unconcentrated and concentrated urine from all the patients. ICT was repeated 1 month after discharge in a group initially testing positive. The authors also studied the ICT in clinically stable human immunodeficiency virus type 1 (HIV1)-infected patients.

S. pneumoniae antigen was detected in all of the 68 (100%) patients tested with definitive pneumococcal pneumonia. In five of these cases ICT was only positive when it had been performed on the patients. The S. pneumoniae antigen was also detected in 36 (69.2%) of 52 patients with probable pneumococcal pneumonia and in 50 of 277 (18%) patients without pneumococcal pneumonia. ICT remained positive in 16 (69.5%) of 23 patients, 1 month after hospital discharge. Nasopharyngeal colonisation with S. pneumoniae was detected in 8 (12%) of 68 clinically stable HIV1 infected patients, but none tested ICT positive.

The Binax NOW® immunochromatographic membrane test is a rapid, sensitive and specific test for detecting pneumococcal community-acquired pneumonia in adults. The test may remain positive for several weeks after pneumococcal pneumonia.

This article has been cited by other articles:

				P. G. Dambrava, A. Torres, X. Valles, J. Mensa, M. A. Marcos, G. Penarroja, M. Camps, R. Estruch, M. Sanchez, R. Menendez, et al. Adherence to guidelines' empirical antibiotic recommendations and community-acquired pneumonia outcome Eur. Respir. J., October 1, 2008; 32(4): 892 - 901. [Abstract] [Full Text] [PDF]

				N. Ehara, K. Fukushima, H. Kakeya, H. Mukae, S. Akamatsu, A. Kageyama, A. Saito, and S. Kohno A novel method for rapid detection of Streptococcus pneumoniae antigen in sputum and its application in adult respiratory tract infections J. Med. Microbiol., July 1, 2008; 57(7): 820 - 826. [Abstract] [Full Text] [PDF]

				M. del Mar Garcia-Suarez, M. D. Cima-Cabal, R. Villaverde, E. Espinosa, M. Falguera, J. R. de Los Toyos, F. Vazquez, and F. J. Mendez Performance of a Pneumolysin Enzyme-Linked Immunosorbent Assay for Diagnosis of Pneumococcal Infections J. Clin. Microbiol., November 1, 2007; 45(11): 3549 - 3554. [Abstract] [Full Text] [PDF]

				J. M. Porcel, A. Ruiz-Gonzalez, M. Falguera, A. Nogues, C. Galindo, J. Carratala, and A. Esquerda Contribution of a Pleural Antigen Assay (Binax NOW) to the Diagnosis of Pneumococcal Pneumonia Chest, May 1, 2007; 131(5): 1442 - 1447. [Abstract] [Full Text] [PDF]

				M. L. Briones, J. Blanquer, D. Ferrando, M. L. Blasco, C. Gimeno, and J. Marin Assessment of Analysis of Urinary Pneumococcal Antigen by Immunochromatography for Etiologic Diagnosis of Community-Acquired Pneumonia in Adults Clin. Vaccine Immunol., October 1, 2006; 13(10): 1092 - 1097. [Abstract] [Full Text] [PDF]

				X. Valles, A. Marcos, M. Pinart, R. Piner, F. Marco, J. M. Mensa, and A. Torres Hospitalized Community-Acquired Pneumonia Due to Streptococcus pneumoniae: Has Resistance to Antibiotics Decreased? Chest, September 1, 2006; 130(3): 800 - 806. [Abstract] [Full Text] [PDF]

				J. A. Jacobs, E. E. Stobberingh, E. I. M. Cornelissen, and M. Drent Detection of Streptococcus pneumoniae Antigen in Bronchoalveolar Lavage Fluid Samples by a Rapid Immunochromatographic Membrane Assay J. Clin. Microbiol., August 1, 2005; 43(8): 4037 - 4040. [Abstract] [Full Text] [PDF]

				K. Stralin, M. S. Kaltoft, H. B. Konradsen, P. Olcen, and H. Holmberg Comparison of Two Urinary Antigen Tests for Establishment of Pneumococcal Etiology of Adult Community-Acquired Pneumonia J. Clin. Microbiol., August 1, 2004; 42(8): 3620 - 3625. [Abstract] [Full Text] [PDF]