ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sargeant, L.
Right arrow Articles by Wareham, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sargeant, L.
Right arrow Articles by Wareham, N.
Eur Respir J 2000; 16: 397-403
Copyright © ERS Journals Ltd 2000

Original Articles

Interaction of vitamin C with the relation between smoking and obstructive airways disease in EPIC Norfolk. European Prospective Investigation into Cancer and Nutrition

LA Sargeant, A Jaeckel, and NJ Wareham

Previous studies have reported an association between plasma vitamin C levels and respiratory function, but have not examined the role of vitamin C as an effect modifier of the relation between cigarette smoking and obstructive airways disease (OAD). This question was investigated in a cross-sectional analysis of a population-based study of 3,714 males and 4,256 females aged 45-74 yrs. Undiagnosed OAD was defined as a forced expiratory volume in one second (FEV1) of <80% of the predicted value and FEV1/forced vital capacity of <70% without self-reported OAD. An increase of 20 micromol x L(-1) (or 1 SD) in plasma vitamin C concentration was associated with a 13% reduction in the risk of having OAD (adjusted odds ratio (OR) (95% confidence interval) 0.87 (0.77-0.98)). The OR for current smokers relative to never smokers within the lowest quintile of plasma vitamin C concentration was 5.93 (3.03-11.61). The risk in the upper four quintiles was 2.84 (1.92-4.19). Within the lowest quintile of plasma vitamin C concentration, the risk in former smokers was strongly related to the time since quitting (interaction significant, p=0.001). These findings support a protective role for vitamin C against the risk of obstructive airways disease and support the hypothesis that vitamin C may be an effect modifier for the adverse effects of smoking on the risk of obstructive airways disease.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
B. J. Proskocil, H. S. Sekhon, J. A. Clark, S. L. Lupo, Y. Jia, W. M. Hull, J. A. Whitsett, B. C. Starcher, and E. R. Spindel
Vitamin C Prevents the Effects of Prenatal Nicotine on Pulmonary Function in Newborn Monkeys
Am. J. Respir. Crit. Care Med., May 1, 2005; 171(9): 1032 - 1039.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. M. McKeever, S. Scrivener, E. Broadfield, Z. Jones, J. Britton, and S. A. Lewis
Prospective Study of Diet and Decline in Lung Function in a General Population
Am. J. Respir. Crit. Care Med., May 1, 2002; 165(9): 1299 - 1303.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. L. CROXTON, G. G. WEINMANN, R. M. SENIOR, and J. R. HOIDAL
Future Research Directions in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., March 15, 2002; 165(6): 838 - 844.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. C. McCLOSKEY, B. D. PATEL, S. J. HINCHLIFFE, E. D. REID, N. J. WAREHAM, and D. A. LOMAS
Siblings of Patients With Severe Chronic Obstructive Pulmonary Disease Have a Significant Risk of Airflow Obstruction
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1419 - 1424.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the European Respiratory Society.