|
 |
|
|||||||
|
|||||||||
Copyright © ERS Journals Ltd 2000
Original Articles |
Diffusion capacity and haemodynamics in primary and chronic thromboembolic pulmonary hypertension
The transfer factor of the lung for carbon monoxide (TL,CO) is decreased in patients with pulmonary hypertension. The pulmonary membrane diffusion capacity (Dm) and pulmonary capillary blood volume (Vc), were studied to establish: 1) the relative contribution of the components of the transfer factor to the decrease in TL,CO; 2) whether differences exist between primary pulmonary hypertension (PPH) and chronic thromboembolic pulmonary hypertension (CTEPH); and 3) the relationship between these parameters and haemodynamic parameters. Dm and Vc were determined in 19 patients with PPH and in eight patients with CTEPH. The patients had been referred for consideration for lung transplantation. Haemodynamic parameters were assessed by heart catheterization. In the PPH group, Vc was reduced in 12 of 19 patients (mean+/-SD Vc 72+/-14% of the predicted value) and Dm in 17 of 19 patients (60+/-22% pred). In the CTEPH group, Vc was reduced in six of eight patients and Dm in seven of eight patients. The mean TL,CO Dm and Vc values were similar to those in the PPH group. The reduction in pulmonary membrane diffusion capacity was significantly greater than that in pulmonary capillary blood volume. No differences in pulmonary and cardiovascular functional values were found between the groups. Right atrial pressure showed a significant negative correlation with pulmonary capillary blood volume and an increased pulmonary vascular resistance was associated with a decrease in pulmonary membrane diffusion capacity. These results suggest pronounced functional impairment of the alveolocapillary membrane in these patients.
This article has been cited by other articles:
|
|
 |
|
  C. M. Kahler Chronic thromboembolic pulmonary hypertension as a cause of dyspnoea in an older patient with a complex history Eur. Respir. Rev., September 1, 2009; 18(113): 170 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Condliffe, D. G. Kiely, J. S. R. Gibbs, P. A. Corris, A. J. Peacock, D. P. Jenkins, K. Goldsmith, J. G. Coghlan, and J. Pepke-Zaba Prognostic and aetiological factors in chronic thromboembolic pulmonary hypertension Eur. Respir. J., February 1, 2009; 33(2): 332 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Corsico, A. M. D'Armini, I. Cerveri, C. Klersy, E. Ansaldo, R. Niniano, E. Gatto, C. Monterosso, M. Morsolini, S. Nicolardi, et al. Long-term Outcome after Pulmonary Endarterectomy Am. J. Respir. Crit. Care Med., August 15, 2008; 178(4): 419 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Alzeer, A. F. Al-Mobeirek, H. A. K. Al-Otair, U. A. F. Elzamzamy, I. A. Joherjy, and A. S. Shaffi Right and Left Ventricular Function and Pulmonary Artery Pressure in Patients With Bronchiectasis* Chest, February 1, 2008; 133(2): 468 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Suntharalingam, R. D Machado, L. D Sharples, M. R Toshner, K. K Sheares, R. J Hughes, D. P Jenkins, R. C Trembath, N. W Morrell, and J. Pepke-Zaba Demographic features, BMPR2 status and outcomes in distal chronic thromboembolic pulmonary hypertension Thorax, July 1, 2007; 62(7): 617 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. van der Lee, P. Zanen, J. C. Grutters, R. J. Snijder, and J. M.M. van den Bosch Diffusing capacity for nitric oxide and carbon monoxide in patients with diffuse parenchymal lung disease and pulmonary arterial hypertension. Chest, February 1, 2006; 129(2): 378 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sofia, M. Maniscalco, P. Carratu, and O. Resta End points for pulmonary arterial hypertension: a way backward Eur. Respir. J., November 1, 2004; 24(5): 890 - 891. [Full Text] [PDF]
|
|
|
|
|
|
M. Bonay, C. Bancal, D. de Zuttere, F. Arnoult, G. Saumon, and F. Camus Normal Pulmonary Capillary Blood Volume in Patients With Chronic Infiltrative Lung Disease and High Pulmonary Artery Pressure Chest, November 1, 2004; 126(5): 1460 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. McGoon, D. Gutterman, V. Steen, R. Barst, D. C. McCrory, T. A. Fortin, and J. E. Loyd Screening, Early Detection, and Diagnosis of Pulmonary Arterial Hypertension: ACCP Evidence-Based Clinical Practice Guidelines Chest, July 1, 2004; 126(1_suppl): 14S - 34S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-G. Sun, J. E. Hansen, R. J. Oudiz, and K. Wasserman Pulmonary function in primary pulmonary hypertension J. Am. Coll. Cardiol., March 19, 2003; 41(6): 1028 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. F. Fedullo, W. R. Auger, K. M. Kerr, and L. J. Rubin Chronic Thromboembolic Pulmonary Hypertension N. Engl. J. Med., November 15, 2001; 345(20): 1465 - 1472. [Full Text] [PDF]
|
|
|
|
|
|
P. Zanen, I. van der Lee, T. van der Mark, and J.M.M. van den Bosch Reference values for alveolar membrane diffusion capacity and pulmonary capillary blood volume Eur. Respir. J., November 1, 2001; 18(5): 764 - 769. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |