S and Z alpha1-antitrypsin alleles are risk factors for bronchial hyperresponsiveness in young farmers: an example of gene/environment interaction

Several studies have found an association between the rare Pi-alleles and asthma or bronchial hyperresponsiveness (BHR). This study deals with the effect of Pi-type on BHR among 2,308 young Danish people living in rural areas with a mean +/- SD age of 19.7+/-2.4 yrs. Interviews, pulmonary function testing, bronchial histamine provocation and skin-prick tests were performed. Serum alpha1-antitrypsin levels were determined and phenotyping was performed by means of isoelectric focusing and the subjects categorized into four groups: 1) MM and MX; 2) MS; 3) MZ; and 4) rare, i.e. SZ, SS and ZZ. Among the farmers, a significant positive trend for sensitization towards house dust mites was found, ranging from 12% in the MM group to 22% in the rare Pi-group. A positive test for trend was found within the Pi-groups in a one-sided test for doctor-diagnosed asthma with a peak prevalence of 40% for these symptoms among smokers in the rare Pi-group. On multiple logistic regression analysis, an increased odds ratio (OR) for BHR was found among farming school attendants with the rare Pi-alleles. The OR (95% confidence interval) was 1.71 (0.84-3.49) for MS, 1.93 (1.10-3.39) for MZ and 4.34 (1.19-15.8) for the rare Pi-group. Such a relationship was not found among the conscripts. These results show that a gene/environment interaction may exist between the farming occupation and the rare Pi-alleles, leading to a higher proportion of bronchial hyperresponsiveness related to the rare Pi-alleles in farming school attendants, in contrast to what is found among other young people living in rural areas.

This article has been cited by other articles:

				F Castro-Giner, F Kauffmann, R de Cid, and M Kogevinas Gene-environment interactions in asthma. Occup. Environ. Med., November 1, 2006; 63(11): 776 - 761. [Full Text] [PDF]

				O. Senn, E. W. Russi, M. Imboden, and N. M. Probst-Hensch {alpha}1-Antitrypsin deficiency and lung disease: risk modification by occupational and environmental inhalants Eur. Respir. J., November 1, 2005; 26(5): 909 - 917. [Abstract] [Full Text] [PDF]

				O S von Ehrenstein, E M Maier, S K Weiland, D Carr, T Hirsch, T Nicolai, A A Roscher, and E von Mutius {alpha}1 Antitrypsin and the prevalence and severity of asthma Arch. Dis. Child., March 1, 2004; 89(3): 230 - 231. [Abstract] [Full Text] [PDF]

				G M Corbo, F Forastiere, N Agabiti, V Dell'Orco, R Pistelli, G Massi, C A Perucci, and S Valente Passive smoking and lung function in {alpha}1-antitrypsin heterozygote schoolchildren Thorax, March 1, 2003; 58(3): 237 - 241. [Abstract] [Full Text] [PDF]

				M. Scuri, Y. Botvinnikova, I. T. Lauredo, and W. M. Abraham Recombinant alpha 1-proteinase inhibitor blocks antigen- and mediator-induced airway responses in sheep J Appl Physiol, December 1, 2002; 93(6): 1900 - 1906. [Abstract] [Full Text] [PDF]