| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Articles |
Chronic persistent asthma is characterized by poorly reversible airflow obstruction and airways inflammation and remodelling. Histopathological studies of airways removed at post mortem from patients with severe asthma reveal marked inflammatory and architectural changes associated with airway wall thickening. Increased airway smooth muscle content, occurring as a result of hyperplastic and/or hypertrophic growth, is believed to be one of the principal contributors to airway wall thickening. In recent years, significant advances have been made in elucidating the mediators and the intracellular pathways that regulate proliferation of airway smooth muscle. The contribution that smooth muscle makes to persistent airflow obstruction may not, however, be limited simply to its increased bulk within the airway wall. Interest is growing in the possibility that reversible phenotypic modulation and increased heterogeneity of airway smooth muscle function may also be a feature of the asthmatic airway. This review focuses on possible mechanisms controlling smooth muscle phenotype heterogeneity as well as on the mediators and intracellular pathways implicated in its cellular proliferation. Particular attention is paid to mechanisms involving activation of the extracellular signal regulated kinase-, protein kinase C- and phosphoinositide 3-kinase-dependent pathways, since these appear to be the major candidate second messenger pathways for G protein- and tyrosine kinase-coupled receptor-stimulated proliferation.
This article has been cited by other articles:
|
|
 |
|
  M. J. Sanderson, P. Delmotte, Y. Bai, and J. F. Perez-Zogbhi Regulation of Airway Smooth Muscle Cell Contractility by Ca2+ Signaling and Sensitivity Proceedings of the ATS, January 1, 2008; 5(1): 23 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. James and S. Wenzel Clinical relevance of airway remodelling in airway diseases Eur. Respir. J., July 1, 2007; 30(1): 134 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G. McVicker, S.-Y. Leung, V. Kanabar, L. M. Moir, K. Mahn, K. F. Chung, and S. J. Hirst Repeated Allergen Inhalation Induces Cytoskeletal Remodeling in Smooth Muscle from Rat Bronchioles Am. J. Respir. Cell Mol. Biol., June 1, 2007; 36(6): 721 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. J. Dekkers, D. Schaafsma, S. A. Nelemans, J. Zaagsma, and H. Meurs Extracellular matrix proteins differentially regulate airway smooth muscle phenotype and function Am J Physiol Lung Cell Mol Physiol, June 1, 2007; 292(6): L1405 - L1413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Takeda, M. Kondo, S. Ito, Y. Ito, K. Shimokata, and H. Kume Role of RhoA Inactivation in Reduced Cell Proliferation of Human Airway Smooth Muscle by Simvastatin Am. J. Respir. Cell Mol. Biol., December 1, 2006; 35(6): 722 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Wenzel and S. Balzar Myofibroblast or smooth muscle: do in vitro systems adequately replicate tissue smooth muscle? Am. J. Respir. Crit. Care Med., August 15, 2006; 174(4): 364 - 365. [Full Text] [PDF]
|
|
|
|
|
|
C. Faisy, F. Pinto, C. Danel, E. Naline, P.-A. Risse, I. Leroy, D. Israel-Biet, J.-Y. Fagon, M.-L. Candenas, and C. Advenier beta2-Adrenoceptor Agonist Modulates Endothelin-1 Receptors in Human Isolated Bronchi Am. J. Respir. Cell Mol. Biol., April 1, 2006; 34(4): 410 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yamaguchi-Okada, S. Nishizawa, M. Koide, and Y. Nonaka Biomechanical and phenotypic changes in the vasospastic canine basilar artery after subarachnoid hemorrhage J Appl Physiol, November 1, 2005; 99(5): 2045 - 2052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Govindaraju, J. G. Martin, K. Maghni, P. Ferraro, and M.-C. Michoud The Effects of Extracellular Purines and Pyrimidines on Human Airway Smooth Muscle Cells J. Pharmacol. Exp. Ther., November 1, 2005; 315(2): 941 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wahl, T. J. Eddinger, and C.-M. Hai Sinusoidal length oscillation- and receptor-mediated mRNA expression of myosin isoforms and {alpha}-SM actin in airway smooth muscle Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1697 - C1708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Woodruff, G. M. Dolganov, R. E. Ferrando, S. Donnelly, S. R. Hays, O. D. Solberg, R. Carter, H. H. Wong, P. S. Cadbury, and J. V. Fahy Hyperplasia of Smooth Muscle in Mild to Moderate Asthma without Changes in Cell Size or Gene Expression Am. J. Respir. Crit. Care Med., May 1, 2004; 169(9): 1001 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Niimi, H. Matsumoto, M. Takemura, T. Ueda, K. Chin, and M. Mishima Relationship of Airway Wall Thickness to Airway Sensitivity and Airway Reactivity in Asthma Am. J. Respir. Crit. Care Med., October 15, 2003; 168(8): 983 - 988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bergner and M. J. Sanderson Selected Contribution: Airway contractility and smooth muscle Ca2+ signaling in lung slices from different mouse strains J Appl Physiol, September 1, 2003; 95(3): 1325 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Benayoun, A. Druilhe, M.-C. Dombret, M. Aubier, and M. Pretolani Airway Structural Alterations Selectively Associated with Severe Asthma Am. J. Respir. Crit. Care Med., May 15, 2003; 167(10): 1360 - 1368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Vermeer, R. Harson, L. A. Einwalter, T. Moninger, and J. Zabner Interleukin-9 Induces Goblet Cell Hyperplasia during Repair of Human Airway Epithelia Am. J. Respir. Cell Mol. Biol., March 1, 2003; 28(3): 286 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gosens, S. A. Nelemans, M. M. Grootte Bromhaar, S. McKay, J. Zaagsma, and H. Meurs Muscarinic M3-Receptors Mediate Cholinergic Synergism of Mitogenesis in Airway Smooth Muscle Am. J. Respir. Cell Mol. Biol., February 1, 2003; 28(2): 257 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C. Pandya, V. A. Snetkov, C. H. C. Twort, J. P. T. Ward, and S. J. Hirst Oxygen regulates mitogen-stimulated proliferation of fetal human airway smooth muscle cells Am J Physiol Lung Cell Mol Physiol, December 1, 2002; 283(6): L1220 - L1230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Faisy, E. Naline, J.-L. Diehl, X. Emonds-Alt, T. Chinet, and C. Advenier In vitro sensitization of human bronchus by beta 2-adrenergic agonists Am J Physiol Lung Cell Mol Physiol, November 1, 2002; 283(5): L1033 - L1042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Jones and M D L Morgan Pulmonary rehabilitation Thorax, May 1, 2002; 57(5): 468 - 468. [Full Text]
|
|
|
|
|
|
M. Sweeney, S. S. McDaniel, O. Platoshyn, S. Zhang, Y. Yu, B. R. Lapp, Y. Zhao, P. A. Thistlethwaite, and J. X.-J. Yuan Role of capacitative Ca2+ entry in bronchial contraction and remodeling J Appl Physiol, April 1, 2002; 92(4): 1594 - 1602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Ammit and R. A. Panettieri Jr. Signal Transduction in Smooth Muscle: Invited Review: The circle of life: cell cycle regulation in airway smooth muscle J Appl Physiol, September 1, 2001; 91(3): 1431 - 1437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Upton, J. Wharton, N. Davie, M. A. Ghatei, D. M. Smith, and N. W. Morrell Differential Adrenomedullin Release and Endothelin Receptor Expression in Distinct Subpopulations of Human Airway Smooth-Muscle Cells Am. J. Respir. Cell Mol. Biol., September 1, 2001; 25(3): 316 - 325. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
