| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Trial |
Autoadjusting nasal continuous positive airway pressure (CPAP) greatly reduces the apnoea/hypopnoea index (AHI), and affords a significant reduction in median pressure (P50) compared-with manually titrated conventional nasal CPAP. The aim of the present study was to test whether these benefits were maintained in the medium term at home, in a double-blind crossover study. Ten sequential subjects (mean AHI 52.9 x h(-1)) were enrolled. After a manual titration, subjects were randomly allocated to 2 months autoadjusting nasal CPAP (AutoSet), followed by 2 months with the AutoSet device in fixed pressure mode at the manually titrated pressure, or vice versa. The machine-scored AHI, P50, and median leak were recorded on 12 nights in each arm, and averaged. Mean+/-SEM AHI was 4.0+/-0.3 x h(-1) in auto mode, and 3.7+/-0.3 x h(-1) in manual mode (NS). Mean+/-SEM P50 was 7.2+/-0.4 cmH2O auto, 9.4+/-0.6 cmH2O manual, average reduction 23+/-4% (p<0.0001). Auto "recommended" pressure was (mean+/-SEM) 10.1+/-0.5 cmH2O (p=0.04 with respect to manual) and peak pressure typically 1 cmH2O higher. Median (+/-SEM) leak was 0.181+/-0.006 L x s(-1) auto (and uncorrelated with AHI or pressure), 0.20+/-0.006 L x s(-1) manual (p=0.003). Compliance was 6.3+/-0.4 h in auto mode and 6.1+/-0.5 h in fixed mode (NS). Apnoea/hypopnoea index during 2 months of home autoadjusting nasal continuous positive airway pressure is comparable to that during conventionally titrated fixed pressure continuous positive airway pressure, while affording a 23% reduction in median pressure but no increase in compliance. Leak did not importantly affect autoadjustment.
This article has been cited by other articles:
|
|
 |
|
  D. Pevernagie, J. F. Masa, J. C. Meurice, R. Farre, O. Marrone, and D. Rodenstein Treatment of obstructive sleep-disordered breathing with positive airway pressure systems Eur. Respir. Rev., December 1, 2007; 16(106): 125 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Nilius, A. Happel, U. Domanski, and K.-H. Ruhle Pressure-Relief Continuous Positive Airway Pressure vs Constant Continuous Positive Airway Pressure: A Comparison of Efficacy and Compliance. Chest, October 1, 2006; 130(4): 1018 - 1024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rigau, J. M. Montserrat, H. Wohrle, D. Plattner, M. Schwaibold, D. Navajas, and R. Farre Bench model to simulate upper airway obstruction for analyzing automatic continuous positive airway pressure devices. Chest, August 1, 2006; 130(2): 350 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nussbaumer, K. E. Bloch, T. Genser, and R. Thurnheer Equivalence of Autoadjusted and Constant Continuous Positive Airway Pressure in Home Treatment of Sleep Apnea Chest, March 1, 2006; 129(3): 638 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P Gordon and M H Sanders Sleep {middle dot} 7: Positive airway pressure therapy for obstructive sleep apnoea/hypopnoea syndrome Thorax, January 1, 2005; 60(1): 68 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. F. Mansour, J. A. Rowley, and M. S. Badr Noninvasive determination of upper airway resistance and flow limitation J Appl Physiol, November 1, 2004; 97(5): 1840 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Pevernagie, P. M. Proot, K. B. Hertegonne, M. C. Neyens, K. P. Hoornaert, and R. A. Pauwels Efficacy of Flow- vs Impedance-Guided Autoadjustable Continuous Positive Airway Pressure: A Randomized Cross-over Trial Chest, July 1, 2004; 126(1): 25 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Noseda, C. Kempenaers, M. Kerkhofs, S. Braun, P. Linkowski, and E. Jann Constant vs Auto-Continuous Positive Airway Pressure in Patients With Sleep Apnea Hypopnea Syndrome and a High Variability in Pressure Requirement Chest, July 1, 2004; 126(1): 31 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Senn, T. Brack, F. Matthews, E. W. Russi, and K. E. Bloch Randomized Short-term Trial of Two AutoCPAP Devices versus Fixed Continuous Positive Airway Pressure for the Treatment of Sleep Apnea Am. J. Respir. Crit. Care Med., December 15, 2003; 168(12): 1506 - 1511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Massie and R. W. Hart Clinical Outcomes Related to Interface Type in Patients With Obstructive Sleep Apnea/Hypopnea Syndrome Who Are Using Continuous Positive Airway Pressure Chest, April 1, 2003; 123(4): 1112 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Massie, N. McArdle, R. W. Hart, W. W. Schmidt-Nowara, A. Lankford, D. W. Hudgel, N. Gordon, and N. J. Douglas Comparison between Automatic and Fixed Positive Airway Pressure Therapy in the Home Am. J. Respir. Crit. Care Med., January 1, 2003; 167(1): 20 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Farre, J. M. Montserrat, J. Rigau, X. Trepat, P. Pinto, and D. Navajas Response of Automatic Continuous Positive Airway Pressure Devices to Different Sleep Breathing Patterns: A Bench Study Am. J. Respir. Crit. Care Med., August 15, 2002; 166(4): 469 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. RANDERATH, O. SCHRAEDER, W. GALETKE, F. FELDMEYER, and K.-H. RUHLE Autoadjusting CPAP Therapy Based on Impedance Efficacy, Compliance and Acceptance Am. J. Respir. Crit. Care Med., March 1, 2001; 163(3): 652 - 657. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
