ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cunningham, S
Right arrow Articles by Marshall, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cunningham, S
Right arrow Articles by Marshall, T.
Eur Respir J 2000; 15: 955-957
Copyright © ERS Journals Ltd 2000

Original Articles

Measurement of inflammatory markers in the breath condensate of children with cystic fibrosis

S Cunningham, McColm JR, LP Ho, AP Greening, and TG Marshall

Identifying noninvasive markers of pulmonary inflammation would be useful in assessing new therapies in children. Breath condensate is a simple and potentially acceptable sample medium even in small children. The technique has previously been used in adults, but not children with cystic fibrosis. The technique was assessed in 36 children with cystic fibrosis (mean age 10.4 yrs) and 17 control subjects, analysing samples for nitrite, interleukin(IL)-8 and salivary and nasal contamination. Correlations were made between levels of the inflammatory markers and forced expiratory volume in one second/forced vital capacity, chest radiograph score and use of inhaled steroids. On samples without significant contamination (<10 u x L(-1) amylase) nitrite was detected in 93% of samples at a median concentration of 3.0 microM compared with 50% of control samples at a median of 0.5 microM. Condensate amylase levels did not correlate with the nitrite value obtained (r=0.31). IL-8 was detected in 33% of CF samples. Breath condensate is an acceptable method of sample collection in children. Nitrite was raised in breath condensate from patients with cystic fibrosis when compared with control subjects.


This article has been cited by other articles:


Home page
 ChestHome page
J.-L. Corhay, M. Henket, D. Nguyen, B. Duysinx, J. Sele, and R. Louis
Leukotriene B4 Contributes to Exhaled Breath Condensate and Sputum Neutrophil Chemotaxis in COPD
Chest, October 1, 2009; 136(4): 1047 - 1054.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Malinovschi, C. Janson, L. Holm, L. Nordvall, and K. Alving
Basal and induced NO formation in the pharyngo-oral tract influences estimates of alveolar NO levels
J Appl Physiol, February 1, 2009; 106(2): 513 - 519.
[Abstract] [Full Text] [PDF]

Home page
 Ther Adv Respir DisHome page
P. Montuschi
Review: Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications
Therapeutic Advances in Respiratory Disease, October 1, 2007; 1(1): 5 - 23.
[Abstract] [PDF]

Home page
 Proc Am Thorac SocHome page
S. D. Sagel, J. F. Chmiel, and M. W. Konstan
Sputum Biomarkers of Inflammation in Cystic Fibrosis Lung Disease
Proceedings of the ATS, August 1, 2007; 4(4): 406 - 417.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J.-L. Corhay, L. Hemelaers, M. Henket, J. Sele, and R. Louis
Granulocyte Chemotactic Activity in Exhaled Breath Condensate of Healthy Subjects and Patients With COPD
Chest, June 1, 2007; 131(6): 1672 - 1677.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
I. Horvath, J. Hunt, P. J. Barnes, and On behalf of the ATS/ERS Task Force on Exhaled Bre
Exhaled breath condensate: methodological recommendations and unresolved questions
Eur. Respir. J., September 1, 2005; 26(3): 523 - 548.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
H Marteus, D C Tornberg, E Weitzberg, U Schedin, and K Alving
Origin of nitrite and nitrate in nasal and exhaled breath condensate and relation to nitric oxide formation
Thorax, March 1, 2005; 60(3): 219 - 225.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. E. Carpagnano, P. J. Barnes, J. Francis, N. Wilson, A. Bush, and S. A. Kharitonov
Breath Condensate pH in Children With Cystic Fibrosis and Asthma: A New Noninvasive Marker of Airway Inflammation?
Chest, June 1, 2004; 125(6): 2005 - 2010.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
E Baraldi, L Ghiro, V Piovan, S Carraro, F Zacchello, and S Zanconato
Safety and success of exhaled breath condensate collection in asthma
Arch. Dis. Child., April 1, 2003; 88(4): 358 - 360.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
W. Formanek, D. Inci, R.P. Lauener, J.H. Wildhaber, U. Frey, and G.L. Hall
Elevated nitrite in breath condensates of children with respiratory disease
Eur. Respir. J., March 1, 2002; 19(3): 487 - 491.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
V. De Rose
Mechanisms and markers of airway inflammation in cystic fibrosis
Eur. Respir. J., February 1, 2002; 19(2): 333 - 340.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. M. MUTLU, K. W. GAREY, R. A. ROBBINS, L. H. DANZIGER, and I. RUBINSTEIN
Collection and Analysis of Exhaled Breath Condensate in Humans
Am. J. Respir. Crit. Care Med., September 1, 2001; 164(5): 731 - 737.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
B. Balint, S.A. Kharitonov, T. Hanazawa, L.E. Donnelly, P.L. Shah, M.E. Hodson, and P.J. Barnes
Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis
Eur. Respir. J., June 1, 2001; 17(6): 1201 - 1207.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the European Respiratory Society.