| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Trial |
The function of the diaphragm and other respiratory muscles during exercise in chronic obstructive pulmonary disease (COPD) remains controversial and few data exist regarding respiratory muscle pressure generation in this situation. The inspiratory pressure/time products of the oesophageal and transdiaphragmatic pressure, and the expiratory gastric pressure/time product during exhaustive treadmill walking in 12 patients with severe COPD are reported. The effect of noninvasive positive pressure ventilation during treadmill exercise was also examined in a subgroup of patients (n=6). During free walking, the inspiratory pressure/time products rose early in the walk and then remained level until the patients were forced to stop because of intolerable dyspnoea. In contrast, the expiratory gastric pressure/time product increased progressively throughout the walk. When patients walked the same distance assisted by noninvasive positive pressure ventilation, a substantial reduction was observed in the inspiratory and expiratory pressure/time products throughout the walk. When patients walked with positive pressure ventilation for as long as they could, the pressure/time products observed at exercise cessation were lower than those observed during exercise cessation after free walking. It is concluded that, in severe chronic obstructive pulmonary disease, inspiratory muscle pressure generation does not increase to meet the demands imposed by exhaustive exercise, whereas expiratory muscle pressure generation rises progressively. Inspiratory pressure support was shown to substantially unload all components of the respiratory muscle pump.
This article has been cited by other articles:
|
|
 |
|
  Rebuttal from Drs. O'Donnell and Webb J Appl Physiol, August 1, 2008; 105(2): 756 - 757. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. M. Luo, H. D. Wu, J. Tang, C. Jolley, J. Steier, J. Moxham, N. S. Zhong, and M. I. Polkey Neural respiratory drive during apnoeic events in obstructive sleep apnoea Eur. Respir. J., March 1, 2008; 31(3): 650 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Romer and M. I. Polkey Exercise-induced respiratory muscle fatigue: implications for performance J Appl Physiol, March 1, 2008; 104(3): 879 - 888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Travers, D. J. Dudgeon, K. Amjadi, I. McBride, K. Dillon, P. Laveneziana, D. Ofir, K. A. Webb, and D. E. O'Donnell Mechanisms of exertional dyspnea in patients with cancer J Appl Physiol, January 1, 2008; 104(1): 57 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dreher, J. H. Storre, and W. Windisch Noninvasive ventilation during walking in patients with severe COPD: a randomised cross-over trial Eur. Respir. J., May 1, 2007; 29(5): 930 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Schonhofer, M. I. Polkey, S. Suchi, and D. Kohler Effect of Home Mechanical Ventilation on Inspiratory Muscle Strength in COPD Chest, December 1, 2006; 130(6): 1834 - 1838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. van 't Hul, R. Gosselink, P. Hollander, P. Postmus, and G. Kwakkel Training with inspiratory pressure support in patients with severe COPD Eur. Respir. J., January 1, 2006; 27(1): 65 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Hopkinson, T. P. Toma, D. M. Hansell, P. Goldstraw, J. Moxham, D. M. Geddes, and M. I. Polkey Effect of Bronchoscopic Lung Volume Reduction on Dynamic Hyperinflation and Exercise in Emphysema Am. J. Respir. Crit. Care Med., March 1, 2005; 171(5): 453 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Fauroux, F. Nicot, S. Essouri, N. Hart, A. Clement, M.I. Polkey, and F. Lofaso Setting of noninvasive pressure support in young patients with cystic fibrosis Eur. Respir. J., October 1, 2004; 24(4): 624 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.K. McConnell, P. Weiner, and L.M. Romer Inspiratory muscle training as a tool for the management of patients with COPD Eur. Respir. J., September 1, 2004; 24(3): 510 - 511. [Full Text] [PDF]
|
|
|
|
|
|
N. Ambrosino and S. Strambi New strategies to improve exercise tolerance in chronic obstructive pulmonary disease Eur. Respir. J., August 1, 2004; 24(2): 313 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P M A Calverley Breathlessness during exercise in COPD: how do the drugs work? Thorax, June 1, 2004; 59(6): 455 - 457. [Full Text] [PDF]
|
|
|
|
|
|
W D C Man, N Mustfa, D Nikoletou, S Kaul, N Hart, G F Rafferty, N Donaldson, M I Polkey, and J Moxham Effect of salmeterol on respiratory muscle activity during exercise in poorly reversible COPD Thorax, June 1, 2004; 59(6): 471 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Aliverti, N Stevenson, R L Dellaca, A Lo Mauro, A Pedotti, and P M A Calverley Regional chest wall volumes during exercise in chronic obstructive pulmonary disease Thorax, March 1, 2004; 59(3): 210 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.K. Simonds Home ventilation Eur. Respir. J., November 16, 2003; 22(47_suppl): 38s - 46s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.P. Highcock, J.M. Shneerson, and I.E. Smith Increased ventilation with NiIPPV does not necessarily improve exercise capacity in COPD Eur. Respir. J., July 1, 2003; 22(1): 100 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Polkey Muscle Metabolism and Exercise Tolerance in COPD* Chest, May 1, 2002; 121(5_suppl): 131S - 135S. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
