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Eur Respir J 2000; 15: 421-423
Copyright © ERS Journals Ltd 2000

Case Studies

Pulmonary veno-occlusive disease in pulmonary Langerhans' cell granulomatosis

K Hamada, S Teramoto, N Narita, E Yamada, K Teramoto, and L Kobzik

This report describes unusual clinical and pathological findings in a 29-yr-old female with pulmonary Langerhans' cell granulomatosis (LCG). During a 7-yr clinical course her condition deteriorated despite corticosteroid therapy, and she died of respiratory failure and pulmonary hypertension. At autopsy, there were widespread pulmonary veno-occlusive disease (PVOD) lesions as well as abundant advanced and healed lesions of pulmonary LCG composed of multiple cysts and stellate fibrosis. The present case demonstrates that pulmonary Langerhans' cell granulomatosis should be considered as a possible cause of pulmonary veno-occlusive disease.


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