Worldwide variations in the prevalence of asthma symptoms: the International Study of Asthma and Allergies in Childhood (ISAAC)

The International Study of Asthma and Allergies in Childhood (ISAAC) was designed to allow comparisons between populations in different countries. ISAAC Phase One, reported here, used standardized simple surveys which were conducted among representative samples of school children from centres in most regions of the world. Two age groups (13-14 and 6-7 yrs) with approximately 3,000 children in each group were studied in each centre. The 13-14 yr olds (n=463,801) were studied in 155 centres (56 countries) and the 6-7 yr olds (n=257,800) were studied in 91 centres (38 countries). There were marked variations in the prevalence of asthma symptoms with up to 15-fold differences between countries. The prevalence of wheeze in the last 12 months ranged from 2.1-32.2% in the older age group and 4.1-32.1% in the younger age group and was particularly high in English speaking countries and Latin America. A video questionnaire completed in the older age group in 99 centres (42 countries) showed a similar pattern. The major differences between populations found in the International Study of Asthma and Allergies in Childhood Phase One are likely to be due to environmental factors. The results provide a framework for studies between populations in contrasting environments which are likely to yield new clues about the aetiology of asthma.

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				J. Manfreda, M. R. Sears, M. R. Becklake, M. Chan-Yeung, H. Dimich-Ward, H. C. Siersted, P. Ernst, L. Sweet, L. Van Til, D. M. Bowie, et al. Geographic and Gender Variability in the Prevalence of Bronchial Responsiveness in Canada Chest, May 1, 2004; 125(5): 1657 - 1664. [Abstract] [Full Text] [PDF]

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				S. W. Turner, L. J. Palmer, P. J. Rye, N. A. Gibson, P. K. Judge, M. Cox, S. Young, J. Goldblatt, L. I. Landau, and P. N. Le Souef The Relationship between Infant Airway Function, Childhood Airway Responsiveness, and Asthma Am. J. Respir. Crit. Care Med., April 15, 2004; 169(8): 921 - 927. [Abstract] [Full Text] [PDF]

				G. J. Rodrigo, C. Rodrigo, and J. B. Hall Acute Asthma in Adults: A Review Chest, March 1, 2004; 125(3): 1081 - 1102. [Abstract] [Full Text] [PDF]

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				S. Farchi, F. Forastiere, N. Agabiti, G. Corbo, R. Pistelli, C. Fortes, V. Dell'Orco, and C.A. Perucci Dietary factors associated with wheezing and allergic rhinitis in children Eur. Respir. J., November 1, 2003; 22(5): 772 - 780. [Abstract] [Full Text] [PDF]

				K. Yeatts, K. Johnston Davis, D. Peden, and C. Shy Health consequences associated with frequent wheezing in adolescents without asthma diagnosis Eur. Respir. J., November 1, 2003; 22(5): 781 - 786. [Abstract] [Full Text] [PDF]

				A. Senthilselvan, J. Lawson, D. C. Rennie, and J. A. Dosman Stabilization of an Increasing Trend in Physician-Diagnosed Asthma Prevalence in Saskatchewan, 1991 to 1998 Chest, August 1, 2003; 124(2): 438 - 448. [Abstract] [Full Text] [PDF]

				K. Yeatts, C. Shy, M. Sotir, S. Music, and C. Herget Health Consequences for Children With Undiagnosed Asthma-like Symptoms Arch Pediatr Adolesc Med, June 1, 2003; 157(6): 540 - 544. [Abstract] [Full Text] [PDF]

				K. Yeatts, K. J. Davis, M. Sotir, C. Herget, and C. Shy Who Gets Diagnosed With Asthma? Frequent Wheeze Among Adolescents With and Without a Diagnosis of Asthma Pediatrics, May 1, 2003; 111(5): 1046 - 1054. [Abstract] [Full Text] [PDF]

				E. C. Mantzouranis, S. A. Boikos, and G. Chlouverakis Throat Clearing -- A Novel Asthma Symptom in Children N. Engl. J. Med., April 10, 2003; 348(15): 1502 - 1503. [Full Text] [PDF]

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				L P Koopman, A Wijga, H A Smit, J C de Jongste, M Kerkhof, J Gerritsen, A P H Vos, R T van Strien, B Brunekreef, and H J Neijens Early respiratory and skin symptoms in relation to ethnic background: the importance of socioeconomic status; the PIAMA study Arch. Dis. Child., December 1, 2002; 87(6): 482 - 488. [Abstract] [Full Text] [PDF]

				S. Rennard, M. Decramer, P.M.A. Calverley, N.B. Pride, J.B. Soriano, P.A. Vermeire, and J. Vestbo Impact of COPD in North America and Europe in 2000: subjects' perspective of Confronting COPD International Survey Eur. Respir. J., October 1, 2002; 20(4): 799 - 805. [Abstract] [Full Text] [PDF]

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				M. Chan-Yeung, L-X. Zhang, D-H. Tu, B. Li, G-X. He, R. Kauppinen, M. Nieminen, and D.A. Enarson The prevalence of asthma and asthma-like symptoms among adults in rural Beijing, China Eur. Respir. J., May 1, 2002; 19(5): 853 - 858. [Abstract] [Full Text] [PDF]

				D. McCann, J. McWhirter, H. Coleman, I. Devall, M. Calvert, K. Weare, and J. Warner The prevalence and management of asthma in primary-aged schoolchildren in the south of England Health Educ. Res., April 1, 2002; 17(2): 181 - 194. [Abstract] [Full Text] [PDF]

				G.W.K. Wong, S.T. Li, D.S.C. Hui, T.F. Fok, N.S. Zhong, Y.Z. Chen, and C.K.W. Lai Individual allergens as risk factors for asthma and bronchial hyperresponsiveness in Chinese children Eur. Respir. J., February 1, 2002; 19(2): 288 - 293. [Abstract] [Full Text] [PDF]

				G Russell Asthma in the transition from childhood to adulthood Thorax, February 1, 2002; 57(2): 96 - 97. [Full Text] [PDF]

				W. Nystad, P. Nafstad, and J. J. K. Jaakkola The effect of respiratory tract infections on reported asthma symptoms Scand J Public Health, January 1, 2002; 30(1): 70 - 75. [Abstract] [PDF]

				M. Palta, M. Sadek-Badawi, M. Sheehy, A. Albanese, M. Weinstein, G. McGuinness, and M. E. Peters Respiratory Symptoms at Age 8 Years in a Cohort of Very Low Birth Weight Children Am. J. Epidemiol., September 15, 2001; 154(6): 521 - 529. [Abstract] [Full Text] [PDF]

				J. C. Celedon, M. E. Soto-Quiros, E. K. Silverman, L. A. Hanson, and S. T. Weiss Risk Factors For Childhood Asthma in Costa Rica Chest, September 1, 2001; 120(3): 785 - 790. [Abstract] [Full Text] [PDF]

				A.J. Henderson, A. Sherriff, K. Northstone, L. Kukla, D. Hruba, Avon Study of Parents and Children Study Team, and European Longitudinal Study of Pregnancy and Child Pre- and postnatal parental smoking and wheeze in infancy: cross cultural differences Eur. Respir. J., August 1, 2001; 18(2): 323 - 329. [Abstract] [Full Text] [PDF]

				M E Penny, S Murad, S S Madrid, T S Herrera, A Pineiro, D E Caceres, and C F Lanata Respiratory symptoms, asthma, exercise test spirometry, and atopy in schoolchildren from a Lima shanty town Thorax, August 1, 2001; 56(8): 607 - 612. [Abstract] [Full Text] [PDF]

				J K Peat, B G Toelle, G B Marks, and C M Mellis Continuing the debate about measuring asthma in population studies Thorax, May 1, 2001; 56(5): 406 - 411. [Abstract] [Full Text]

				P. Ellwood, M.I. Asher, B. Bjorksten, M. Burr, N. Pearce, and C.F Robertson Diet and asthma, allergic rhinoconjunctivitis and atopic eczema symptom prevalence: an ecological analysis of the International Study of Asthma and Allergies in Childhood (ISAAC) data Eur. Respir. J., March 1, 2001; 17(3): 436 - 443. [Abstract] [Full Text] [PDF]

				A. W Stewart, E. A Mitchell, N. Pearce, D. P Strachan, and S. K Weiland The relationship of per capita gross national product to the prevalence of symptoms of asthma and other atopic diseases in children (ISAAC) Int. J. Epidemiol., February 1, 2001; 30(1): 173 - 179. [Abstract] [Full Text] [PDF]

				P Vineis, L Miligi, P Crosignani, A Fontana, G Masala, O Nanni, V Ramazzotti, S Rodella, E Stagnaro, R Tumino, et al. Delayed infection, family size and malignant lymphomas J Epidemiol Community Health, December 1, 2000; 54(12): 907 - 911. [Abstract] [Full Text]

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