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Eur Respir J 1998; 11:1185-1187
Copyright ©ERS Journals Ltd 1998

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Case Studies

Alpha-fetoprotein producing pulmonary blastoma in a patient with systemic sclerosis: pathogenetic analysis

I Kasuga, D Miyamoto, Y Ichinose, W Chimangul, K Minemura, K Utsumi, M Yonemaru, H Serizawa, Y Ebihara, and K Toyama

We describe a rare case of pulmonary blastoma complicated with systemic sclerosis. The serum alpha-fetoprotein level was elevated at presentation and the biopsied tumour stained positively against anti-alpha-fetoprotein antibody. The alpha-fetoprotein produced autonomously by tumour cells was of yolk-sac origin. Although the pathogenesis of pulmonary blastoma has not been clarified, we suggest that this pulmonary blastoma is a type of yolk-sac tumour.




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