| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Articles |
It has been hypothesized but not firmly established that sleep-related hypoxaemia could favour the development of pulmonary hypertension in chronic obstructive pulmonary disease (COPD) patients without marked daytime hypoxaemia. We have investigated the relationships between pulmonary function data, sleep-related desaturation and daytime pulmonary haemodynamics in a group of 94 COPD patients not qualifying for conventional O2 therapy (daytime arterial oxygen tension (Pa,O2) in the range 7.4-9.2 kPa (56-69 mmHg)). Nocturnal desaturation was defined by spending > or = 30% of the recording time with a transcutaneous O2 saturation < 90%. An obstructive sleep apnoea syndrome was excluded by polysomnography. Sixty six patients were desaturators (Group 1) and 28 were nondesaturators (Group 2). There was no significant difference between Groups 1 and 2 with regard to pulmonary volumes and Pa,O2 (8.4+/-0.6 vs 8.4+/-0.4 kPa (63+/-4 vs 63+/-3 mmHg)) but arterial carbon dioxide tension (Pa,CO2) was higher in Group 1 (6.0+/-0.7 vs 53+/-0.5 kPa (45+/-5 vs 40+/-4 mmHg); p<0.0001). Mean pulmonary artery pressure (Ppa) was very similar in the two groups (2.6+/-0.7 vs 2.5+/-0.6 kPa (19+/-5 vs 19+/-4 mmHg)). No individual variable or combination of variables could predict the presence of pulmonary hypertension. It is concluded that in these patients with chronic obstructive pulmonary disease with modest daytime hypoxaemia, functional and gasometric variables (with the noticeable exception of arterial carbon dioxide tension) cannot predict the presence of nocturnal desaturation; and that mean pulmonary artery pressure is not correlated with the degree and duration of nocturnal hypoxaemia. These results do not support the hypothesis that sleep-related hypoxaemia favours the development of pulmonary hypertension.
This article has been cited by other articles:
|
|
 |
|
  A. Chaouat, R. Naeije, and E. Weitzenblum Pulmonary hypertension in COPD Eur. Respir. J., November 1, 2008; 32(5): 1371 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Albert and P. M. A. Calverley Drugs (including oxygen) in severe COPD Eur. Respir. J., May 1, 2008; 31(5): 1114 - 1124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Krachman, O. A. Minai, and S. M. Scharf Sleep Abnormalities and Treatment in Emphysema Proceedings of the ATS, May 1, 2008; 5(4): 536 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Nisbet, T Eaton, C Lewis, W Fergusson, and J Kolbe Overnight prescription of oxygen in long term oxygen therapy: time to reconsider the guidelines? Thorax, September 1, 2006; 61(9): 779 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Toraldo, G. Nicolardi, F. De Nuccio, R. Lorenzo, and N. Ambrosino Pattern of Variables Describing Desaturator COPD Patients, as Revealed by Cluster Analysis Chest, December 1, 2005; 128(6): 3828 - 3837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Jounieaux, D. Rose, and P. Aubry Relationships between exercise-induced pulmonary hypertension and nocturnal desaturation Eur. Respir. J., June 1, 2005; 25(6): 1126 - 1127. [Full Text] [PDF]
|
|
|
|
|
|
J. Zielinski Effects of intermittent hypoxia on pulmonary haemodynamics: animal models versus studies in humans Eur. Respir. J., January 1, 2005; 25(1): 173 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T K Marras, W MacNee, and P M A Calverley Management of COPD Thorax, November 1, 2003; 58(11): 1006 - 1006. [Full Text] [PDF]
|
|
|
|
|
|
C. A. Lewis, T. E. Eaton, W. Fergusson, K. F. Whyte, J. E. Garrett, and J. Kolbe Home Overnight Pulse Oximetry in Patients With COPD: More Than One Recording May Be Needed Chest, April 1, 2003; 123(4): 1127 - 1133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W MacNee and P M A Calverley Chronic obstructive pulmonary disease * 7: Management of COPD Thorax, March 1, 2003; 58(3): 261 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Weitzenblum and A. Chaouat Hypoxic pulmonary hypertension in man: what minimum daily duration of hypoxaemia is required? Eur. Respir. J., August 1, 2001; 18(2): 251 - 253. [Full Text] [PDF]
|
|
|
|
|
|
A. Chaouat, E. Weitzenblum, R. Kessler, R. Schott, C. Charpentier, P. Levi-Valensi, J. Zielinski, L. Delaunois, R. Cornudella, and J. Moutinho dos Santos Outcome of COPD patients with mild daytime hypoxaemia with or without sleep-related oxygen desaturation Eur. Respir. J., May 1, 2001; 17(5): 848 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Plywaczewski, P. Sliwinski, A. Nowinski, D. Kaminski, and J. Zielinski Incidence of Nocturnal Desaturation While Breathing Oxygen in COPD Patients Undergoing Long-term Oxygen Therapy Chest, March 1, 2000; 117(3): 679 - 683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. KESSLER, M. FALLER, G. FOURGAUT, B. MENNECIER, and E. WEITZENBLUM Predictive Factors of Hospitalization for Acute Exacerbation in a Series of 64 Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., January 1, 1999; 159(1): 158 - 164. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
