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Eur Respir J 1997; 10: 1405-1407
Copyright © ERS Journals Ltd 1997

Case Studies

Propylthiouracil-induced alveolar haemorrhage associated with antineutrophil cytoplasmic antibody

M Ohtsuka, Y Yamashita, M Doi, and S Hasegawa

Propylthiouracil (PTU) is known to cause vasculitis as a rare complication. We report the case of a patient who developed alveolar haemorrhage and haematuria whilst treated with PTU. The serum was positive for antineutrophil cytoplasmic antibody (ANCA) with myeloperoxidase (MPO) specificity (MPO-ANCA). All symptoms resolved completely after discontinuation of PTU. Alveolar haemorrhage or pulmonary-renal syndrome associated with antineutrophil cytoplasmic antibody with myeloperoxidase specificity may be a new complication of propylthiouracil therapy.


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Copyright © 1997 by the European Respiratory Society.