| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Trial |
In animal models of pulmonary inflammation, neutrophils exhibit a dramatic influx of glucose in periods of high metabolic activity. This information was utilized to develop a technique, involving positron emission tomography (PET) of 2-[18F]-fluoro-2-deoxy-D-glucose (18FDG), which measures neutrophil activity in situ. This technique was applied in a comparative study of neutrophil function in patients with acute lobar pneumonia or bronchiectasis. Neutrophil emigration was measured by gamma-scintigraphy of intravenously injected 111In-labelled granulocytes and neutrophil activity determined by PET of 18FDG. Neutrophil emigration was evident in 4 out of 5 bronchiectasis patients, whilst no emigration was apparent in the two pneumonia patients studied, consistent with animal studies showing maximum emigration soon after challenge. In contrast, 18FDG uptake was markedly increased in 4 out of 5 pneumonia patients but not in the patients with bronchiectasis. Localization of radioactivity to neutrophils was confirmed by microautoradiography of lavage fluid in a patient with pneumonia. These results suggest that the elevated uptake of glucose by neutrophils during the inflammatory response is a postmigratory event, most likely reflecting the respiratory burst, and that high levels of neutrophil emigration are not necessarily associated with significantly increased metabolic activity of these cells.
This article has been cited by other articles:
|
|
 |
|
  T. Schroeder, M. F. Vidal Melo, G. Musch, R. S. Harris, J. G. Venegas, and T. Winkler Image-Derived Input Function for Assessment of 18F-FDG Uptake by the Inflamed Lung J. Nucl. Med., November 1, 2007; 48(11): 1889 - 1896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Dolovich and D. P. Schuster Positron Emission Tomography and Computed Tomography versus Positron Emission Tomography Computed Tomography: Tools for Imaging the Lung Proceedings of the ATS, August 1, 2007; 4(4): 328 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Schuster, S. L. Brody, Z. Zhou, M. Bernstein, R. Arch, D. Link, and M. Mueckler Regulation of lipopolysaccharide-induced increases in neutrophil glucose uptake Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L845 - L851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Schroeder, M. F. Vidal Melo, G. Musch, R. S. Harris, T. Winkler, and J. G. Venegas PET Imaging of Regional 18F-FDG Uptake and Lung Function After Cigarette Smoke Inhalation J. Nucl. Med., March 1, 2007; 48(3): 413 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Meller, C.-O. Sahlmann, and A. K. Scheel 18F-FDG PET and PET/CT in Fever of Unknown Origin J. Nucl. Med., January 1, 2007; 48(1): 35 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Harris and D. P. Schuster Visualizing lung function with positron emission tomography J Appl Physiol, January 1, 2007; 102(1): 448 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Chen, T. W. Ferkol, M. A. Mintun, J. E. Pittman, D. B. Rosenbluth, and D. P. Schuster Quantifying Pulmonary Inflammation in Cystic Fibrosis with Positron Emission Tomography Am. J. Respir. Crit. Care Med., June 15, 2006; 173(12): 1363 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Chen, D. B. Rosenbluth, M. A. Mintun, and D. P. Schuster FDG-PET imaging of pulmonary inflammation in healthy volunteers after airway instillation of endotoxin J Appl Physiol, May 1, 2006; 100(5): 1602 - 1609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Jones Inflammation Imaging Proceedings of the ATS, December 1, 2005; 2(6): 545 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhou, J. Kozlowski, A. L. Goodrich, N. Markman, D. L. Chen, and D. P. Schuster Molecular imaging of lung glucose uptake after endotoxin in mice Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L760 - L768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhou, J. Kozlowski, and D. P. Schuster Physiologic, Biochemical, and Imaging Characterization of Acute Lung Injury in Mice Am. J. Respir. Crit. Care Med., August 1, 2005; 172(3): 344 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dolovich and R. Labiris Imaging Drug Delivery and Drug Responses in the Lung Proceedings of the ATS, December 1, 2004; 1(4): 329 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Chen, M. A. Mintun, and D. P. Schuster Comparison of Methods to Quantitate 18F-FDG Uptake with PET During Experimental Acute Lung Injury J. Nucl. Med., September 1, 2004; 45(9): 1583 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Chen and D. P. Schuster Positron emission tomography with [18F]fluorodeoxyglucose to evaluate neutrophil kinetics during acute lung injury Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L834 - L840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Krupnick, J. V. Lombardi, F. H. Engels, D. Kreisel, H. Zhuang, A. Alavi, and J. P. Carpenter 81-Fluorodeoxyglucose Positron Emission Tomography as a Novel Imaging Tool for the Diagnosis of Aortoenteric Fistula and Aortic Graft Infection: A Case Report Vascular and Endovascular Surgery, September 1, 2003; 37(5): 363 - 366. [Abstract] [PDF]
|
|
|
|
 |
|
 N.R. Labiris, C. Nahmias, A.P. Freitag, M.L. Thompson, and M.B. Dolovich Uptake of 18fluorodeoxyglucose in the cystic fibrosis lung: a measure of lung inflammation? Eur. Respir. J., May 1, 2003; 21(5): 848 - 854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.A. Jones, P.S. Marino, B.H. Shakur, and N.W. Morrell In vivo assessment of lung inflammatory cell activity in patients with COPD and asthma Eur. Respir. J., April 1, 2003; 21(4): 567 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Jones, K. A. Cadwallader, J. F. White, M. Uddin, A. M. Peters, and E. R. Chilvers Dissociation Between Respiratory Burst Activity and Deoxyglucose Uptake in Human Neutrophil Granulocytes: Implications for Interpretation of 18F-FDG PET Images J. Nucl. Med., May 1, 2002; 43(5): 652 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. JEAN, S. REZAIGUIA-DELCLAUX, C. DELACOURT, R. LECLERCQ, C. LAFUMA, C. BRUN-BUISSON, A. HARF, and C. DELCLAUX Protective Effect of Endotoxin Instillation on Subsequent Bacteria-induced Acute Lung Injury in Rats Am. J. Respir. Crit. Care Med., December 1, 1998; 158(6): 1702 - 1708. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
