ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sauty, A
Right arrow Articles by Nicod, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sauty, A
Right arrow Articles by Nicod, L.
Eur Respir J 1997; 10: 2907-2912
Copyright © ERS Journals Ltd 1997

Case Studies

Pulmonary fibrosis with predominant CD8 lymphocytic alveolitis and anti-Jo-1 antibodies

A Sauty, T Rochat, OD Schoch, J Hamacher, AM Kurt, JM Dayer, and LP Nicod

Interstitial lung disease (ILD) is a complication of polymyositis (PM) and dermatomyositis (DM). It often manifests itself in association with myositis-specific antisynthetase autoantibodies, among which anti-Jo-1 antibodies are the most commonly encountered. In contrast, ILD associated with anti-Jo-1 antibodies without muscle involvement is rare and not well characterized. We report four patients presenting with ILD associated with anti-Jo-1 antibodies. Histological findings of transbronchial biopsies disclosed a pattern consistent with nonspecific interstitial pneumonitis, a CD8+ lymphocytosis was found in bronchoalveolar lavage. Only one of these patients developed an "antisynthetase syndrome" with PM, after nearly 2 yrs of severe ILD. The clinical conditions of all four cases showed stabilization or improvement when cyclosporine was added to their immunosuppressive treatment. These cases confirm that a CD8+ lymphocytic interstitial lung disease may be the first, and sole manifestation of autoimmune disease associated with anti-Jo-1 antibodies. Furthermore, they suggest that this form of interstitial lung disease apparently has a poor response to steroids and cytotoxic drugs, but may respond to moderate doses of cyclosporine and azathioprine in addition to low doses of steroids.


This article has been cited by other articles:


Home page
 ThoraxHome page
A U Wells, N Hirani, and on behalf of the BTS Interstitial Lung Disease Gui
Interstitial lung disease guideline
Thorax, September 1, 2008; 63(Suppl_5): v1 - v58.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
L. P. Nicod
From the authors
Eur. Respir. J., July 1, 2008; 32(1): 245 - 246.
[Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
I. G. Luzina, N. W. Todd, A. T. Iacono, and S. P. Atamas
Roles of T lymphocytes in pulmonary fibrosis
J. Leukoc. Biol., February 1, 2008; 83(2): 237 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G. E. Tzelepis, S. P. Toya, and H. M. Moutsopoulos
Occult connective tissue diseases mimicking idiopathic interstitial pneumonias
Eur. Respir. J., January 1, 2008; 31(1): 11 - 20.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Guglielmi, T. M. Merz, M. Gugger, C. Suter, and L. P. Nicod
Acute respiratory distress syndrome secondary to antisynthetase syndrome is reversible with tacrolimus
Eur. Respir. J., January 1, 2008; 31(1): 213 - 217.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
I Tillie-Leblond, M Wislez, D Valeyre, B Crestani, A Rabbat, D Israel-Biet, M Humbert, L J Couderc, B Wallaert, and J Cadranel
Interstitial lung disease and anti-Jo-1 antibodies: difference between acute and gradual onset
Thorax, January 1, 2008; 63(1): 53 - 59.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
T. Yokoyama, T. Sakamoto, N. Shida, M. Kinoshita, Y. Kunou, R. Karukaya, M. Takamatsu, and H. Aizawa
Fatal Rapidly Progressive Interstitial Pneumonitis Associated With Amyopathic Dermatomyositis and CD8 T Lymphocytes
J Intensive Care Med, May 1, 2005; 20(3): 160 - 163.
[Abstract] [PDF]

Home page
 Eur Respir JHome page
J-M. Naccache, M. Kambouchner, F. Girard, M. Antoine, A. Parrot, J. Piquet, M. Brauner, and D. Valeyre
Relapse of respiratory insufficiency one year after organising pneumonia
Eur. Respir. J., December 1, 2004; 24(6): 1062 - 1065.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Zhang-Hoover and J. Stein-Streilein
Tolerogenic APC Generate CD8+ T Regulatory Cells That Modulate Pulmonary Interstitial Fibrosis
J. Immunol., January 1, 2004; 172(1): 178 - 185.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. W. DOUGLAS, H. D. TAZELAAR, T. E. HARTMAN, R. P. HARTMAN, P. A. DECKER, D. R. SCHROEDER, and J. H. RYU
Polymyositis-Dermatomyositis-associated Interstitial Lung Disease
Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1182 - 1185.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
J Lampa, I Nennesmo, H Einarsdottir, and I Lundberg
MRI guided muscle biopsy confirmed polymyositis diagnosis in a patient with interstitial lung disease
Ann Rheum Dis, April 1, 2001; 60(4): 423 - 426.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
O. EICKELBERG, A. PANSKY, E. KOEHLER, M. BIHL, M. TAMM, P. HILDEBRAND, A. P. PERRUCHOUD, M. KASHGARIAN, and M. ROTH
Molecular mechanisms of TGF-{beta} antagonism by interferon {gamma} and cyclosporine A in lung fibroblasts
FASEB J, March 1, 2001; 15(3): 797 - 806.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Zhang-Hoover, A. Sutton, and J. Stein-Streilein
CD40/CD40 Ligand Interactions Are Critical for Elicitation of Autoimmune-Mediated Fibrosis in the Lung
J. Immunol., March 1, 2001; 166(5): 3556 - 3563.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the European Respiratory Society.